Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Definition
US FDA substance register · UNII G07GZ97H65 · registered name Clotrimazole · single chemical substance
Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group. It has a role as an antiinfective agent, a xenobiotic and an environmental contaminant. It is a member of imidazoles, a member of monochlorobenzenes, an imidazole antifungal drug and a conazole antifungal drug.
Source: PubChem
Cosmetic roles
Safety & regulatory references
- Banned
- ASEAN
Source: ASEAN Cosmetic Directive
SCCS opinion: Opinion concerning Azole Antimycotic Resistance
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 23593-75-1
- EC No.EU chemical inventory number
- 245-764-8
- DTXSIDUS EPA chemical ID
- DTXSID7029871
- DTXCIDUS EPA compound ID
- DTXCID009871
- IUPAC
- 1-[(2-Chlorophenyl)di(phenyl)methyl]-1H-imidazole
- Molecular formula
- C22H17ClN2
- Molecular weight
- 344.84 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide1
- Anti-dandruff (EPA)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Efficacy of topical clotrimazole in treatment of otomycosis. · 2013
- Vulvar Allergic Contact Dermatitis from Clotrimazole · 2010
- Use of clotrimazole/betamethasone diproprionate by family physicians. · 2000
- OCULAR TOXICITY OF TOPICAL CLOTRIMAZOLE PREPARATIONS · 1987
- Effectiveness of a topical antifungal agent (clotrimazole) in dogs. · 1981
Linked databases 16
- ASEAN Cosmetic Directive
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese