Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
定义
美国FDA 物质登记 · UNII G07GZ97H65 · 登记名称 Clotrimazole · 单一化学物质
Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group. It has a role as an antiinfective agent, a xenobiotic and an environmental contaminant. It is a member of imidazoles, a member of monochlorobenzenes, an imidazole antifungal drug and a conazole antifungal drug.
来源: PubChem
化妆品中的作用
安全与法规参考
- 禁用
- 东盟
来源: 东盟化妆品指令
SCCS opinion: Opinion concerning Azole Antimycotic Resistance
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 23593-75-1
- EC No.欧盟化学品目录编号
- 245-764-8
- DTXSID美国EPA化学品编号
- DTXSID7029871
- DTXCID美国EPA化合物编号
- DTXCID009871
- IUPAC
- 1-[(2-Chlorophenyl)di(phenyl)methyl]-1H-imidazole
- 分子式
- C22H17ClN2
- 分子量
- 344.84 g/mol
产品实际使用的用途
这是向美国 EPA 申报含该成分的 2 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Biocide1
- Anti-dandruff (EPA)1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 1 项、眼部试验 1 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 2 项试验
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
来源: 美国EPA CompTox
相关文献
- Efficacy of topical clotrimazole in treatment of otomycosis. · 2013
- Vulvar Allergic Contact Dermatitis from Clotrimazole · 2010
- Use of clotrimazole/betamethasone diproprionate by family physicians. · 2000
- OCULAR TOXICITY OF TOPICAL CLOTRIMAZOLE PREPARATIONS · 1987
- Effectiveness of a topical antifungal agent (clotrimazole) in dogs. · 1981