Cobalt dichloride is a cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride.
Definition
US FDA substance register · UNII EVS87XF13W · registered name COBALTOUS CHLORIDE · single chemical substance
Cobalt dichloride is a cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants. It has a role as a sensitiser, a calcium channel blocker, a two-colour indicator and an allergen. It is a cobalt salt and an inorganic chloride. It contains a cobalt(2+).
Source: PubChem
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Korea’s toxic-substance GHS classification: Danger · H317 (category 1) · H334 (category 1) · H319 (category 2) · +6 more
EU Cosmetics Regulation, Annex II (prohibited substances), entry 453
Restriction II/453
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name 塩化コバルト: 本品は、コバルトの塩化物であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 7646-79-9
- EC No.EU chemical inventory number
- 231-589-4
- DTXSIDUS EPA chemical ID
- DTXSID9040180
- DTXCIDUS EPA compound ID
- DTXCID7020180
- IUPAC
- Cobalt(2+) dichloride
- Molecular formula
- Cl2Co
- Molecular weight
- 129.83 g/mol
Measured properties
- pH
- 4.6
- Melting/freezing point
- 737 ℃
- Initial boiling point and range
- 1049 ℃(101.325 kPa)
- Flammability (solid, gas)
- not flammable
- Vapour pressure
- 75 ㎜Hg (818℃)
- Water solubility
- 585.9 g/ℓ (20℃, pH: 7)
- Vapour density
- 3.36 g/㎤
- Relative density
- 3.36 (25/4℃)
- n-Octanol/water partition coefficient (Kow)
- 0.85
- Molecular weight
- 129.839
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- No specific technical function1
- Soil amendments1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
8 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 12 studies
- Skin sensitization - Category 1
Skin Sensitization · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3B (Category 3)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 2002-04-24 according to - Category 1
Skin Sensitization · Screening - Category 2
Skin Irritation · Screening - Skin Sens. 1
Skin Sensitization · Authoritative - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) adopted 2002-04-24 according to - Category 2
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Protective roles of NRF2 signaling pathway in cobalt chloride‐induced hypoxic cytotoxicity in human HaCaT keratinocytes · 2018
- Elicitation threshold of cobalt chloride: analysis of patch test dose–response studies · 2016
- Cobalt chloride stimulates phosphoinositide 3-kinase/Akt signaling through the epidermal growth factor receptor in oral squamous cell carcinoma. · 2010
- Occupational asthma caused by cobalt chloride in a diamond polisher after cessation of occupational exposure: a case report. · 2005
- The effect of cobalt chloride on skin flap survival. · 1996
Linked databases 22
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese