COLLAGEN

Collagens. A fibrous protein comprising one third of the total protein in mammalian organisms. It is a polypeptide containing three peptide chains and rich in proline and hydroxyproline

美国FDA 物质登记 · UNII 8JC99XGU4W · 登记名称 MARINE COLLAGEN, SOLUBLE · 混合物

来源: 美国FDA 物质识别码（UNII）

Collagen supplementation and topical use are typically safe and well tolerated with minimal adverse effects reported. Formulation quality affects topical collagen stability and efficacy.

Collagen is an abundant extracellular matrix protein forming the scaffold structure of skin, bones, and connective tissues. Aging causes collagen to degrade and production to decline, leading to wrinkles, sagging, and thinning skin. Collagen peptides in supplements or topical products can stimulate fibroblasts to increase collagen and elastin synthesis, restoring skin structure and resilience. Oral collagen peptides are absorbed and distributed to connective tissue, promoting tighter skin and improved hydration. Topical collagen provides surface hydration though its high molecular weight limits penetration into deeper layers. Additionally, collagen exhibits antioxidant properties reducing oxidative stress, boosts skin repair processes, and slows aging by downregulating metalloproteinases responsible for collagen breakdown. Clinical studies indicate improvements in skin elasticity, density, wrinkle reduction, hydration, and texture with collagen supplementation or topical use.

未列入韩国有毒物质 GHS 分类 · 现有化学物质

来源: 韩国有毒物质 GHS 信息（环境公团）

Other restriction: ban substances that deplete the ozone layer

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Safety Assessment of Skin and Connective Tissue-Derived Proteins and Peptides as Used in Cosmetics

来源: 美国CIR 安全性评估