Ingredient Dictionary

COUMARIN

Coumarin is a chromenone having the keto group located at the 2-position.

How much products actually contain

No product states its amount yet.

Of the products containing it, 53 list it before the 1% line and 442 after it (usually 1% or less).

Products using this ingredient

12 of 495 confirmed · likeliest to carry enough first · See all 495

Definition

Coumarin is a chromenone having the keto group located at the 2-position. It has a role as a fluorescent dye, a plant metabolite and a human metabolite.

Source: PubChem

US FDA substance register · UNII A4VZ22K1WT · registered name COUMARIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Restricted: International fragrance standard (IFRA) · United Kingdom

Source: EU Cosmetics Regulation · IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

European Union

Other : The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)g when its concentration exceeds: - 0.001% in leave-on products - 0.01% in rinse-off products

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 77

Source: EU restricted substances (Annex III)

Restriction III/77

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name クマリン: 本品は、次の化学式で表される芳香族ラクトンである。

Source: JCIA labelling names (Japan)

Names & identifiers

COUMARININCI쿠마린Korean label name (MFDS standard)2H-1-Benzopyran-2-oneSynonymクマリンJapanese labelling name

CAS No.chemical registry number: 91-64-5
EC No.EU chemical inventory number: 202-086-7
DTXSIDUS EPA chemical ID: DTXSID7020348
DTXCIDUS EPA compound ID: DTXCID50348

IUPAC: 2H-1-Benzopyran-2-one
Molecular formula: C9H6O2
Molecular weight: 146.145 g/mol

Measured properties

Appearance: solid
Colour: colourless
Melting/freezing point: 68~70 ℃
Initial boiling point and range: 297~299 ℃
Flash point: 150 ℃
Vapour pressure: 0.13 ㎪(at 106 ℃)
Water solubility: 1900 ㎎/ℓ(at 20 ℃)
Vapour density: 5.04 (air=1)
Relative density: 0.935 (at 20 ℃/4 ℃)
n-Octanol/water partition coefficient (Kow): 1.39
Molecular weight: 146.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1,006 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance991
Deodorizer6
Processing aids not otherwise specified2
Dye2
Pigment2
Monomers1
Flavouring and nutrient1
Brightener1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 2 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Classification not possible
Skin Irritation · Screening
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 6.3A (Category 2)
Skin Irritation · Read Across
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) Magnusson and Kligman guinea pig maximisation test
Classification not possible
Skin Sensitization · Screening
Classification not possible
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) equivalent or similar to