Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters.
Definition
US FDA substance register · UNII 877GWI46C2 · registered name CROCIN · single chemical substance
Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol. It has a role as an antioxidant, a plant metabolite, a histological dye and a food colouring. It is a diterpenoid, a diester and a disaccharide derivative. It is functionally related to a gentiobiose and a beta-D-gentiobiosyl crocetin.
Source: PubChem
Crocin is the organic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 42553-65-1
- EC No.EU chemical inventory number
- 255-881-6
- DTXSIDUS EPA chemical ID
- DTXSID7046172
- DTXCIDUS EPA compound ID
- DTXCID201457
- IUPAC
- Bis(2S,3R,4S,5S,6R)[3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-he ptaenedioate (non-preferred name)
- Molecular formula
- C44H64O24
- Molecular weight
- 976.972 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye1
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Recent Insights into the Potential Roles of Crocin and Safranal in Alleviating Skin Aging: A Mini-Review · 2025
- Prevention of toxic effects of orally administered tartrazine by crocin in Wistar rats · 2021
- Crocin ameliorated skin tissue inflammation in atopic dermatitis in mice · 2020
- Crocin enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress. · 2020
- Protective effect of crocin on ultraviolet B-induced dermal fibroblast photoaging · 2018
Linked databases 14
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese