Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
定義
Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. It is a tertiary alpha-hydroxy ketone, a cucurbitacin and a secondary alpha-hydroxy ketone. It derives from a hydride of a lanostane.
出典: PubChem
米国FDA 物質登録 · UNII 0115W5MABF · 登録名 CUCURBITACIN B · 単一の化学物質
化粧品での役割
肌を良い状態に保つ（CosIng 包括分類）SKIN CONDITIONING
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
CUCURBITACIN BINCI큐커비타신B韓国の表示名（食薬処標準名）
- CAS No.化学物質登録番号
- 6199-67-3
- DTXSID米国EPA化学物質番号
- DTXSID501316196
- DTXCID米国EPA化合物番号
- DTXCID401746059
- IUPAC
- (2S,4R,23E)-2,16alpha,20-Trihydroxy-9alpha,10,14-trimethyl-1,11,22-trioxo-8beta-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
- 分子式
- C32H46O8
- 分子量
- 558.712 g/mol
測定された物性
- 性状
- Solid, [Merck Index] · CRYSTALS FROM ABSOLUTE ETHANOL
- 融点
- 184-186 °C
物質そのものを測定した値で、原料商品の規格ではありません。
出典: PubChem
関連文献
- Reduction of Cancer Stem Cells and Invasiveness of Human Melanoma and Breast Cancer by Cucurbitacin B from Lagenaria siceraria · 2023
- Cucurbitacin B, Purified and Characterized From the Rhizome of Corallocarpus epigaeus Exhibits Anti-Melanoma Potential · 2022
- Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling · 2020
- Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer · 2019
- Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR‐146b‐5p and lncRNA‐AFAP1‐AS1 · 2018