Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
定义
Cucurbitacin B is a cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated. It is a tertiary alpha-hydroxy ketone, a cucurbitacin and a secondary alpha-hydroxy ketone. It derives from a hydride of a lanostane.
来源: PubChem
美国FDA 物质登记 · UNII 0115W5MABF · 登记名称 CUCURBITACIN B · 单一化学物质
化妆品中的作用
保持肌肤良好状态（CosIng 泛分类）SKIN CONDITIONING
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
CUCURBITACIN BINCI큐커비타신B韩国标示名称（食药处标准名）
- CAS No.化学物质登记号
- 6199-67-3
- DTXSID美国EPA化学品编号
- DTXSID501316196
- DTXCID美国EPA化合物编号
- DTXCID401746059
- IUPAC
- (2S,4R,23E)-2,16alpha,20-Trihydroxy-9alpha,10,14-trimethyl-1,11,22-trioxo-8beta-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
- 分子式
- C32H46O8
- 分子量
- 558.712 g/mol
实测物性
- 性状
- Solid, [Merck Index] · CRYSTALS FROM ABSOLUTE ETHANOL
- 熔点
- 184-186 °C
这是对物质本身测得的数值，并非原料商品的规格。
来源: PubChem
相关文献
- Reduction of Cancer Stem Cells and Invasiveness of Human Melanoma and Breast Cancer by Cucurbitacin B from Lagenaria siceraria · 2023
- Cucurbitacin B, Purified and Characterized From the Rhizome of Corallocarpus epigaeus Exhibits Anti-Melanoma Potential · 2022
- Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling · 2020
- Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer · 2019
- Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR‐146b‐5p and lncRNA‐AFAP1‐AS1 · 2018