Ingredient Dictionary

CYCLOHEXANONE

Cyclohexanone is a cyclic ketone that consists of cyclohexane bearing a single oxo substituent.

Definition

Cyclohexanone is a cyclic ketone that consists of cyclohexane bearing a single oxo substituent. It has a role as a human xenobiotic metabolite.

Source: PubChem

US FDA substance register · UNII 5QOR3YM052 · registered name Cyclohexanone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENTGives the product a scentPERFUMING

Safety & regulatory references

Korea’s toxic-substance GHS classification: Danger · H311 (category 3) · H335 (category 3) · H341 (category 2) · +4 more

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

CYCLOHEXANONEINCI사이클로헥산온Korean label name (MFDS standard)

CAS No.chemical registry number: 108-94-1
EC No.EU chemical inventory number: 203-631-1
DTXSIDUS EPA chemical ID: DTXSID6020359
DTXCIDUS EPA compound ID: DTXCID00359

IUPAC: Cyclohexanone
Molecular formula: C6H10O
Molecular weight: 98.145 g/mol

Measured properties

Appearance: Cyclohexanone appears as a colorless to pale yellow liquid with a pleasant odor. Less dense than water. Flash point 111 °F. Vapors heavier than air. Used to make nylon, as a chemical reaction medium, and as a solvent. · Liquid, CBI
Odour: ODOR REMINISCENT OF PEPPERMINT & ACETONE · ... Peppermint- or acetone-like odor.
Boiling point: 312.1 °F at 760 mmHg (NTP, 1992) · 155.4 °C
Melting point: 3 °F (NTP, 1992) · -31 °C
Solubility: 50 to 100 mg/mL at 64 °F (NTP, 1992) · 25000 mg/L (at 25 °C)
Odour threshold: 0.88 ppm
Melting/freezing point: -31 ℃
Initial boiling point and range: 154.3 ℃(at 1013 hPa)
Flash point: 44 ℃
Evaporation rate: 0.29
Upper/lower flammability or explosive limits: 9.4 / 1.1 % (100℃)
Vapour pressure: 500 ㎩(20℃)
Water solubility: 8.7 g/100㎖(20℃)
Vapour density: 3.4
Relative density: 0.95
n-Octanol/water partition coefficient (Kow): 0.81
Auto-ignition temperature: 420 ℃(at 1013 hPa)
Viscosity: 2.2 cP(25℃)
Molecular weight: 98.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 29 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent12
Fragrance3
Fuel agents2
Intermediate2
Plasticizer2
Flavouring and nutrient2
Fuel1
Corrosion inhibitor1

4 other uses

Diluent1
Processing aids not otherwise specified1
Defoamer1
Cleaning agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 3 eye studies are on record.

Classed as highly irritating1Classed as moderate2

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Category 2
Skin Irritation · Screening
Skin corrosion/irritation - Category 2
Skin Irritation · Screening
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Category 1
Skin Sensitization · Screening
Category 2A
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Serious eye damage/eye irritation - Category 2A
Eye Irritation · Screening