Dodecamethylcyclohexasiloxane is an organosilicon compound.
How much products actually contain
No product states its amount yet.
Of the products containing it, 563 list it before the 1% line and 68 after it (usually 1% or less).
Products using this ingredient
12 of 616 confirmed · likeliest to carry enough first · See all 616
HYGGEEFresh Vegan Tone-up Sun Cream
Elizabeth ArdenElizabeth Arden Flawless Finish Skincaring Foundation
LUVUMBamboo Hyaluronic Acid Moisture Sun Cream 50ml
CURLYSHYLLSilky Oil Serum 70ml
AbibHeartleaf Cream Calming Tube 75ml
Briall HommeNW Natural Whitening Tone-up Cream 50ml
SOME BY MIRetinol Intense Reactivating Serum
Dr. OracleDr. Oracle 21STAY A-Tera Cream
COSNORICOSNORI Avocado Eye Cream 30ml
COSNORICOSNORI Avocado Eye Cream 15ml
SOME BY MISOME BY MI Retinol Intense Reactivating Serum 30ml
SOME BY MISOME BY MI Retinol Intense Reactivating Serum 50ml
Definition
US FDA substance register · UNII XHK3U310BA · registered name CYCLOMETHICONE 6 · single chemical substance
Dodecamethylcyclohexasiloxane is an organosilicon compound.
Source: PubChem
Cyclohexasiloxane is the cyclic dimethyl polysiloxane that conforms to the formula, where n equals 6, and the other components of cyclomethicone (where n equals 4, 5, or 7) are present at levels of less than 1%.
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance · priority-management substance
Restriction Restricted under COMMISSION REGULATION (EU) 2024/1328. 1. Shall not be placed on the market (a) as a substance on its own; (b) as a constituent of other substances; or (c) in mixtures; in a concentration equal to or greater than 0,1 % by weight of the respective substance after 6 June 2026. [...] 3. By way of derogation: (a) for D4 and D5 in wash-off cosmetic products, paragraph 1, point (c), shall apply after 31 January 2020. For the purposes of this point, “wash-off cosmetic products” means cosmetic products as defined in Article 2(1), point (a), of Regulation (EC) No 1223/2009 of the European Parliament and of the Council (*1) that, under normal conditions of use, are washed off with water after application; (b) for all cosmetic products other than the ones mentioned in paragraph 3(a), paragraph 1 shall apply after 6 June 2027.
Source: EU CosIng ingredient list
Reviewed by CIR: Safety assessment of Cyclomethicone, Cyclotetrasiloxane, Cyclopentasiloxane, Cyclohexasiloxane and Cycloheptasiloxane
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name シクロヘキサシロキサン: 本品は、環状ポリシロキサンであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 540-97-6
- EC No.EU chemical inventory number
- 208-762-8
- DTXSIDUS EPA chemical ID
- DTXSID6027183
- DTXCIDUS EPA compound ID
- DTXCID507183
- IUPAC
- Dodecamethylcyclohexasiloxane
- Molecular formula
- C12H36O6Si6
- Molecular weight
- 444.924 g/mol
Measured properties
- Appearance
- CBI, Liquid, Other Solid · Oily liquid
- Odour
- Odorless
- Boiling point
- 245 °C
- Melting point
- -3 °C
- Solubility
- In water, 0.0051 mg/L at 23 °C
- Density
- 0.9672 g/cu cm at 25 °C
- Stability
- Stable under recommended storage conditions.
- Viscosity
- 6.62 cSt · 5.66 ㎟/s(20 °C, QSAR)
- Melting/freezing point
- -3.0 ℃
- Initial boiling point and range
- 245 ℃
- Flash point
- 91 ℃
- Vapour pressure
- 0.0225 ㎜Hg( 25 ℃)
- Water solubility
- 0.0051 ㎎/ℓ( 25 ℃)
- Relative density
- 0.9762
- n-Octanol/water partition coefficient (Kow)
- 6.33
- Auto-ignition temperature
- 368 ℃
- Molecular weight
- 44.93
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 36 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner14
- Solvent5
- Degradant/impurity (EPA)3
- Intermediate3
- Diluent2
- Surfactant (surface active agent)2
- Lubricating agent2
- Dispersing agent2
3 other uses
- Anti-adhesive/cohesive1
- Terminator/blocker1
- Viscosity modifier1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Risk assessment of cyclohexasiloxane D6 in cosmetic products · 2024
- Phytochemical and GC-MS Analysis of Dendrophthoe falcata (L.f.) Ettingsh Stem · 2019
- Multi-Target Anti-Aging Mechanisms of Multani Mitti (Fuller’s Earth): Integrating Enzyme Inhibition and Molecular Docking for Cosmeceuticals · 2025
- Evaluation of anti-inflammatory, analgesic and TNF-α inhibition (upon RAW 264.7 cell line) followed by selection of extract (leaf and stem) with respect to potency to introduce anti-oral-ulcer model obtained from Olax psittacorum (Lam.) Vahl in addition to GC-MS illustration. · 2020
- Safety Assessment of Cyclomethicone, Cyclotetrasiloxane, Cyclopentasiloxane, Cyclohexasiloxane, and Cycloheptasiloxane · 2011
Linked databases 14
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US FDA Unique Ingredient Identifier (UNII)