Definition
US FDA substance register · UNII D21000AYE2 · registered name 2-PENTANONE, 4-CYCLOHEXYL-4-METHYL- · single chemical substance
Cosmetic roles
Gives the product a scentPERFUMING
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
CYCLOHEXYL-4-METHYLPENTAN-2-ONEINCI2-Pentanone, 4-cyclohexyl-4-methyl-Synonym
- CAS No.chemical registry number
- 4927-39-3
- EC No.EU chemical inventory number
- 225-562-6
- DTXSIDUS EPA chemical ID
- DTXSID8047682
- DTXCIDUS EPA compound ID
- DTXCID6027682
- IUPAC
- 4-Cyclohexyl-4-methylpentan-2-one
- Molecular formula
- C12H22O
- Molecular weight
- 182.307 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 2 eye studies are on record.
Classed as highly irritating1Classed as low2
The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) Primary irritation to the skin is measured by a patch-test technique on the abraded and intact skin of albino rabbits. equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) May 1981 according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) Commission Directive 84/449/EEC, September 1984 according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) May 1981Reference: B. Magnusson and A. M. Kligman: "The identifieation of contact allergens by animal assay. The guinea pig maximization test" (I Invest. Dermatol., 52, 268-276, 1969) and "Allergie Contact Dermatitis in the Guinea Pig" (Thomas Publishers, Springfield, Illinois, 1970). - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) February 1987 according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) July 2015 according to
Source: US EPA CompTox dashboard
Linked databases 11
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata