Ingredient Dictionary

CYCLOHEXYLAMINE

Cyclohexylamine is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent.

Definition

Cyclohexylamine is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent. It has a role as a mouse metabolite and a human xenobiotic metabolite. It is a conjugate base of a cyclohexylammonium.

Source: PubChem

US FDA substance register · UNII I6GH4W7AEG · registered name Cyclohexylamine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cyclohexylamine is the organic compound that conforms to the formula:

Cosmetic roles

Prevents corrosion of packaging and equipmentANTICORROSIVEKeeps pH steadyBUFFERING

Safety & regulatory references

Banned: ASEAN · China · European Union · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H314 (category 1) · H361 (category 2) · H226 (category 3) · +2 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1503

Source: EU prohibited substances (Annex II)

Restriction II/1503 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

CYCLOHEXYLAMINEINCI사이클로헥실아민Korean label name (MFDS standard)CyclohexanamineSynonym

CAS No.chemical registry number: 108-91-8
EC No.EU chemical inventory number: 203-629-0
DTXSIDUS EPA chemical ID: DTXSID1023996
DTXCIDUS EPA compound ID: DTXCID203996

IUPAC: Cyclohexanamine
Molecular formula: C6H13N
Molecular weight: 99.177 g/mol

Measured properties

Appearance: Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia. Flash point 90 °F. Irritates the eyes and respiratory system. Skin contact may cause burns. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. · Liquid
Odour: Strong, fishy, amine odor.
Boiling point: 274.1 °F at 760 mmHg (EPA, 1998) · 134.5 °C @ 760 mm Hg
Melting point: 0.1 °F (EPA, 1998) · -17.7 °C
Solubility: Very soluble (NTP, 1992) · Very soluble in ethanol, miscible in ether and acetone.
Density: 0.8647 at 77 °F (EPA, 1998) - Less dense than water, will float · 0.8647 @ 25 °C/25 °C
Viscosity: 2.10 Pa*s at 20 °C · 0.75 cP(30°C)
pH: STRONG BASE
Dissociation constant: pKa = 10.63 (conjugate acid)
Melting/freezing point: -17.7 ℃
Initial boiling point and range: 134.5 ℃
Flash point: 28 ℃
Upper/lower flammability or explosive limits: 9.4 / 1.5 %
Vapour pressure: 1.4 ㎪(20℃)
Water solubility: 1000 g/ℓ
Vapour density: 3.42
Relative density: 0.86 (25℃)
n-Octanol/water partition coefficient (Kow): 1.4 (20°C)
Auto-ignition temperature: 293 ℃
Molecular weight: 99.18

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 22 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Corrosion inhibitor7
pH regulating agent3
Processing aids not otherwise specified3
Intermediate3
Fuel2
Heat transferring agent1
Catalyst1
Solvent1

1 other uses

Lubricating agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 2 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Category 8.2B (Category 1B)
Skin Irritation · Read Across
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 1
Skin Irritation · Screening
Skin Corr. 1B
Skin Irritation · Authoritative
Classification not possible
Skin Sensitization · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Category 1
Eye Irritation · Screening