Cysteamine is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.
How much products actually contain
No product states its amount yet.
Of the products containing it, 1 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
1 of 1 confirmed · likeliest to carry enough first
Definition
Cysteamine is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2. It has a role as a geroprotector, a radiation protective agent, a mouse metabolite and a human metabolite. It is a thiol and an amine. It is functionally related to an ethylamine. It is a conjugate base of a cysteaminium.
Source: PubChem
US FDA substance register · UNII 5UX2SD1KE2 · registered name CYSTEAMINE · single chemical substance
Cysteamine is the organic compound that conforms to the formula.
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name システアミン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 60-23-1
- DTXSIDUS EPA chemical ID
- DTXSID3022875
- DTXCIDUS EPA compound ID
- DTXCID902875
- IUPAC
- 2-Aminoethane-1-thiol
- Molecular formula
- C2H7NS
- Molecular weight
- 77.15 g/mol
Measured properties
- Appearance
- Solid · Crystals by sublimation in vacuo
- Odour
- Disagreeable odor
- Boiling point
- 133.6±23.0 · Decomposes
- Melting point
- 67-71 · 97-98.5 °C
- Solubility
- Freely soluble in water. · Soluble in methanol, ethanol
- Dissociation constant
- 10.4 · pKa1 = 8.19 (thiol), pKa2 = 10.75 (amine) (c= 0.01 moles/L, mixed constants)
- Melting/freezing point
- 97~98.5 ℃
- n-Octanol/water partition coefficient (Kow)
- -0.2 (est.)
- Molecular weight
- 77.1503
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Processing aids not otherwise specified3
- Hair waving or straightening (EPA)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Classification not possible
Skin Irritation · Screening - SkinSens1
Skin Sensitization · QSAR Predicted - Classification not possible
Skin Sensitization · Screening - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Development of cysteamine loaded liposomes in liquid and dried forms for improvement of cysteamine stability. · 2020
- Effect of cysteamine hydrochloride-loaded liposomes on skin depigmenting and penetration. · 2021
- Challenges for cysteamine stabilization, quantification, and biological effects improvement · 2020
- [Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis]. · 2017
- Increased human dermal microvascular endothelial cell survival induced by cysteamine · 2013
Linked databases 17
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese