Decursinol is an organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8.
Definition
US FDA substance register · UNII UBI4YB704B · registered name DECURSINOL · single chemical substance
Decursinol is an organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8. It is isolated from the roots of Angelica gigas and has been found to possess significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). It has a role as a metabolite, an analgesic, an antineoplastic agent and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a delta-lactone, an organic heterotricyclic compound, a secondary alcohol and a cyclic ether.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 23458-02-8
- DTXSIDUS EPA chemical ID
- DTXSID70178008
- DTXCIDUS EPA compound ID
- DTXCID60100499
- IUPAC
- (7S)-7-Hydroxy-8,8-dimethyl-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one
- Molecular formula
- C14H14O4
- Molecular weight
- 246.262 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis · 2021
- Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. · 2019
- High-performance liquid chromatography determination and pharmacokinetics of coumarin compounds after oral administration of Samul-Tang to rats · 2014
- Cosmetic Effect of Angelica gigas Nakai Root Extracts · 2009
Linked databases 13
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata