Decursinol is an organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8.
定義
米国FDA 物質登録 · UNII UBI4YB704B · 登録名 DECURSINOL · 単一の化学物質
Decursinol is an organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8. It is isolated from the roots of Angelica gigas and has been found to possess significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). It has a role as a metabolite, an analgesic, an antineoplastic agent and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a delta-lactone, an organic heterotricyclic compound, a secondary alcohol and a cyclic ether.
出典: PubChem
化粧品での役割
安全性・規制情報
Other restriction: ban substances that deplete the ozone layer
出典: EU CosIng 成分リスト
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
- CAS No.化学物質登録番号
- 23458-02-8
- DTXSID米国EPA化学物質番号
- DTXSID70178008
- DTXCID米国EPA化合物番号
- DTXCID60100499
- IUPAC
- (7S)-7-Hydroxy-8,8-dimethyl-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one
- 分子式
- C14H14O4
- 分子量
- 246.262 g/mol
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品2件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Antioxidant1
- Softener and conditioner1
出典: 米国EPA CompTox
関連文献
- Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis · 2021
- Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. · 2019
- High-performance liquid chromatography determination and pharmacokinetics of coumarin compounds after oral administration of Samul-Tang to rats · 2014
- Cosmetic Effect of Angelica gigas Nakai Root Extracts · 2009