Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen.
Definition
US FDA substance register · UNII W2F8059T80 · registered name DEMETHOXYCURCUMIN · single chemical substance
Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, an enone, a beta-diketone and a diarylheptanoid.
Source: PubChem
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name デメトキシクルクミン: 本品は、次の化学式で表される芳香族化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 22608-11-3
- DTXSIDUS EPA chemical ID
- DTXSID00873751
- DTXCIDUS EPA compound ID
- DTXCID001011975
- IUPAC
- (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
- Molecular formula
- C20H18O5
- Molecular weight
- 338.359 g/mol
Measured properties
- Appearance
- Solid
- Melting point
- 168 °C
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Poly (vinyl alcohol)-gelatin-sericin copolymerized film fortified with vesicle-entrapped demethoxycurcumin/bisdemethoxycurcumin for improved stability, antibacterial, anti-inflammatory, and skin tissue regeneration. · 2023
- MOLECULAR INTERACTION OF CURCUMIN, DEMETHOXYCURCUMIN, BISDEMETHOXYCURCUMIN, AND TURMERONE OF Curcuma longa WITH TYROSINASE AND TYROSINASE-RELATED PROTEIN-1 · 2021
- Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells · 2020
- Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties · 2018
- Demethoxycurcumin in combination with ultraviolet radiation B induces apoptosis through the mitochondrial pathway and caspase activation in A431 and HaCaT cells · 2017
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese