What is this ingredient?

미국 FDA 물질 등록 · UNII 005990WHZZ · 등록명 Deoxycholic acid · 단일 화학물질

Ingredient Dictionary

DEOXYCHOLIC ACID

Deoxycholic acid is a bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.

Definition

US FDA substance register · UNII 005990WHZZ · registered name Deoxycholic acid · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Deoxycholic acid is a bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively. It has a role as a human blood serum metabolite. It is a C24-steroid, a dihydroxy-5beta-cholanic acid and a bile acid. It is a conjugate acid of a deoxycholate.

Source: PubChem

Deoxycholic Acid is an organic acid derived from bile. It conforms to the formula:

Cosmetic roles

Makes skin soft and smoothSKIN CONDITIONING - EMOLLIENTKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGDraws in and holds moistureHUMECTANT

More data — names, identifiers, properties, test records, literature

Names & identifiers

DEOXYCHOLIC ACIDINCI디옥시콜릭애씨드Korean label name (MFDS standard)Cholan-24-oic acid, 3,12-dihydroxy-, (3.alpha.,5.beta.,12.alpha.)-Synonym

CAS No.chemical registry number: 83-44-3
EC No.EU chemical inventory number: 201-478-5
DTXSIDUS EPA chemical ID: DTXSID0042662
DTXCIDUS EPA compound ID: DTXCID8022662

IUPAC: 3alpha,12alpha-Dihydroxy-5beta-cholan-24-oic acid
Molecular formula: C24H40O4
Molecular weight: 392.58 g/mol

Measured properties

Appearance: Solid, [Merck Index] White powder, [MSDSonline] · Solid
Melting point: 177 °C · 176-178 °C
Solubility: 43.6 mg/L (at 20 °C) · SOLUBILITY IN WATER: GREATER THAN 333 G/L @ 15 °C /NA SALT/
Dissociation constant: pK= 6.58
Initial boiling point and range: 211.5 ℃(EXP)
Water solubility: 34940 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 0.54 (EST)

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner2
Emulsifier1
Humectant1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 0 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 1 studies

SkinIrr2
Skin Irritation · QSAR Predicted