What is this ingredient?

미국 FDA 물질 등록 · UNII Q7WP157PTD · 등록명 Diacetone alcohol · 단일 화학물질

All ingredients

Ingredient Dictionary

DIACETONE ALCOHOL

Diacetone alcohol is a beta-hydroxy ketone formed by hydroxylation of 4-methylpentan-2-one at the 4-position.

How much products actually contain

No product states its amount yet.

Of the products containing it, 405 list it before the 1% line and 9 after it (usually 1% or less).

Products using this ingredient

12 of 414 confirmed · likeliest to carry enough first · See all 414

Definition

US FDA substance register · UNII Q7WP157PTD · registered name Diacetone alcohol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Diacetone alcohol is a beta-hydroxy ketone formed by hydroxylation of 4-methylpentan-2-one at the 4-position. It has been isolated from Achnatherum robustum. It has a role as a plant metabolite.

Source: PubChem

Diacetone Alcohol is the ketone that conforms to the formula

Cosmetic roles

Gives the product a scentPERFUMINGBase that dissolves other ingredientsSOLVENTListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Safety Assessment of Diacetone Alcohol as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ジアセトンアルコール: 本品は、次の化学式で表されるケトンである。

Source: JCIA labelling names (Japan)

Names & identifiers

DIACETONE ALCOHOLINCI다이아세톤알코올Korean label name (MFDS standard)2-Pentanone, 4-hydroxy-4-methyl-SynonymジアセトンアルコールJapanese labelling name

CAS No.chemical registry number: 123-42-2
EC No.EU chemical inventory number: 204-626-7
DTXSIDUS EPA chemical ID: DTXSID6024917
DTXCIDUS EPA compound ID: DTXCID304917

IUPAC: 4-Hydroxy-4-methylpentan-2-one
Molecular formula: C6H12O2
Molecular weight: 116.16 g/mol

Measured properties

Appearance: Diacetone alcohol appears as a clear colorless liquid with a pleasant odor. Flash point below 141 °F. Less dense than water. Vapors heavier than air. · CBI, Liquid
Odour: FAINT PLEASANT ODOR · Minty odor
Boiling point: 328 °F at 760 mmHg (USCG, 1999) · 167.9 °C AT 760 MM HG, 108.2 °C AT 100 MM HG, 72.0 °C AT 20 MM HG, 58.8 °C AT 10 MM HG, 22.0 °C AT 1.0 MM HG
Melting point: -45 °F (USCG, 1999) · -44 °C
Solubility: Miscible (NIOSH, 2024) · MISCIBLE WITH WATER, ALCOHOL, ETHER, OTHER SOLVENTS
Density: 0.938 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.9306 @ 25 °C/4 °C (0.940 FOR TECHNICAL GRADE)
Stability: DECOMPOSED BY PROLONGED EXPOSURE TO ALKALIS & BY DISTILLATION AT ATMOSPHERIC PRESSURE
Colour: colourless
Melting/freezing point: -47 ℃
Initial boiling point and range: 169~171 ℃
Flash point: 58 ℃(c.c.)
Evaporation rate: 0.14
Upper/lower flammability or explosive limits: 6.9 / 1.8 %
Vapour pressure: 0.108 ㎪ (20℃)
Water solubility: 100 g/100㎖
Vapour density: 4
Relative density: 0.93
n-Octanol/water partition coefficient (Kow): 0.445
Auto-ignition temperature: 640 ℃
Molecular weight: 116.159

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 22 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent13
Deodorizer2
Pigment2
Biocide1
Intermediate1
Flux agent1
Flavouring and nutrient1
Fragrance1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 7 eye studies are on record.

Classed as moderate1Classed as low3

The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 13 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Category 6.3B (Category 3)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) 1992
Classification not possible
Skin Sensitization · Screening
Category 2
Skin Irritation · Screening
Eye irritation - category 2A
Eye Irritation · Screening
Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: Draize method as modified in the US Federal Registern (1963) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Eye Irrit. 2
Eye Irritation · Authoritative
Category 2A
Eye Irritation · Screening