Diazolidinylurea is an imidazolidine-2,4-dione.
- Korean limit
- 0.50%
How much products actually contain
No product states its amount yet.
Of the products containing it, 5 list it before the 1% line and 4 after it (usually 1% or less).
Products using this ingredient
9 of 9 confirmed · likeliest to carry enough first
Curl JunkieCurl Junkie CURLS IN A BOTTLE! HAIR STYLING SOLUTION
Curl JunkieCurl Junkie SMOOTHING LOTION LEAVE-IN
O'Keeffe'sHealthy Feet Foot Cream Tube 85g
VerbVerb Sea Spray
Curl JunkieCurl Junkie BEAUTICURLS ARGAN & OLIVE OIL CONDITIONER
Curl JunkieCurl Junkie PATTERN PUSHA - HAIR STYLING GEL
Miss Jessie'sMiss Jessie's Coily Custard - Curl Refresher
Curl JunkieCurl Junkie REPAIR ME! RECONSTRUCTIVE HAIR TREATMENT
American CrewAmerican Crew POMADE
Definition
US FDA substance register · UNII H5RIZ3MPW4 · registered name DIAZOLIDINYL UREA · mixture
Diazolidinylurea is an imidazolidine-2,4-dione.
Source: PubChem
Diazolidinyl Urea is the heterocyclic substituted urea that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Maximum concentration permitted at final product : 0.5%
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.5%
Taiwan
- Maximum concentration : 0.5%
- 0.5%
China
- Maximum concentration : 0.5%
South Korea
- Maximum concentration : 0.50%
European Union
- Maximum concentration in ready for use preparation : 0.5%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex V (allowed preservatives), entry 46 · maximum concentration 0.5%
Restriction V/46 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006
Reviewed by CIR: Final Report on the Safety Assessment of Diazolidinyl Urea
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 78491-02-8
- EC No.EU chemical inventory number
- 278-928-2
- DTXSIDUS EPA chemical ID
- DTXSID0029559
- DTXCIDUS EPA compound ID
- DTXCID009559
- IUPAC
- N-[1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N,N'-bis(hydroxymethyl)urea
- Molecular formula
- C8H14N4O7
- Molecular weight
- 278.221 g/mol
Measured properties
- Appearance
- Liquid · solid
- Odour
- odourless
- Water solubility
- 0.556 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- -7.49
- Molecular weight
- 278.22
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative9
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPPTS 870.2500 (Acute Dermal Irritation) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3B (Category 3)
Skin Irritation · Read Across - Severe Irritation
eye irritation: in vivo · Screening · EPA OPPTS 870.2400 (Acute Eye Irritation) according to - Severe Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
Source: US EPA CompTox dashboard
Related literature
- Non-sensitizing Alternatives to Diazolidinyl Urea and Imidazolidinyl Urea as Preservatives in Cosmetics · 2026
- Erythrocyte Toxicities of Imidazolidinyl Urea and Diazolidinyl Urea · 2013
- Allergic contact dermatitis in health care workers to diazolidinyl urea present in antimicrobial hand gel · 2011
- Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea · 2006
- ROAT: morphology of ROAT on arm, neck and face in formaldehyde and diazolidinyl urea sensitive individuals · 2006
Linked databases 25
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed preservatives (Annex V)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS) 2
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English