Definition
US FDA substance register · UNII 4X371TMK9K · registered name DIBUTYL MALEATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 105-76-0
- EC No.EU chemical inventory number
- 203-328-4
- DTXSIDUS EPA chemical ID
- DTXSID3026724
- DTXCIDUS EPA compound ID
- DTXCID206724
- IUPAC
- Dibutyl (2Z)-but-2-enedioate
- Molecular formula
- C12H20O4
- Molecular weight
- 228.288 g/mol
Measured properties
- Appearance
- Liquid · liquid
- Colour
- colourless
- Melting/freezing point
- -85 ℃
- Initial boiling point and range
- 274~281 ℃ ()
- Flash point
- &, gt, 110 ℃
- Upper/lower flammability or explosive limits
- -3.4 / 0.5 %
- Vapour pressure
- 0.000623 ㎜Hg (at 25℃)
- Water solubility
- 500 ㎎/ℓ (at 25℃.)
- Vapour density
- 7.9 (0.9930-0.9964g/mL)
- n-Octanol/water partition coefficient (Kow)
- 4.16 ()
- Auto-ignition temperature
- 280 ℃
- Viscosity
- 3.7 cSt (at 38℃)
- Molecular weight
- 228.29
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 12 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Plasticizer8
- Processing aids not otherwise specified2
- Lubricating agent1
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Occupational allergic contact dermatitis to dibutyl maleate and dibutyl fumarate present in a safety shoe: A reason for concern? · 2021
- Dibutyl Maleate and Dibutyl Fumarate Enhance Contact Sensitization to Fluorescein Isothiocyanate in Mice. · 2016
- Determination of Dimethyl Fumarate and Other Fumaric and Maleic Acid Diesters in Desiccants and Consumer Products in Japan · 2011
- Esters of Aromatic Mono‐, Di‐, and Tricarboxylic Acids, Aromatic Diacids and Di‐, Tri‐, Or Polyalcohols · 2001
- Contact dermatitis from dibutyl maleate · 1985
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese