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Ingredient Dictionary

DIBUTYL PHTHALATE

Molecular structure

Definition

Di-n-butyl Phthalate (DBP) can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to The National Toxicology Program's Center for the Evaluation of Risks to Human Reproduction.

Source: PubChem

US FDA substance register · UNII 2286E5R2KE · registered name DIBUTYL PHTHALATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps a film flexiblePLASTICISERListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEGives the product a scentPERFUMINGBase that dissolves other ingredientsSOLVENT

Safety & regulatory references

Banned
Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H360 (category 1B) · H400 (category 1)

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 675

Source: EU prohibited substances (Annex II)

Restriction II/675

Source: EU CosIng ingredient list

Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2002/2003

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Dibutyl Phthalate, Dimethyl Phthalate, and Diethyl Phthalate

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Re-evaluation: Dibutyl, Dimethyl and Diethyl Phthalate and Butyl Benzyl Phthalate

Source: US Cosmetic Ingredient Review (CIR)

CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Amended Safety Assessment of Dibutyl Phthalate,Diethyl Phthalate, and Dimethyl Phthalate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name フタル酸ジブチル: 本品は、フタル酸とブタノール（＊）のジエステルであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

DIBUTYL PHTHALATEINCI다이부틸프탈레이트Korean label name (MFDS standard)1,2-Benzenedicarboxylic acid, 1,2-dibutyl esterSynonymフタル酸ジブチルJapanese labelling name
CAS No.chemical registry number
84-74-2
EC No.EU chemical inventory number
201-557-4
DTXSIDUS EPA chemical ID
DTXSID2021781
DTXCIDUS EPA compound ID
DTXCID301781
IUPAC
Dibutyl benzene-1,2-dicarboxylate
Molecular formula
C16H22O4
Molecular weight
278.348 g/mol

Measured properties

Appearance
N-butyl phthalate is a colorless oily liquid. It is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since it is a liquid it can easily penetrate the soil and contaminate groundwater and nearby streams. It is combustible though it may take some effort to ignite. It is used in paints and plastics and as · Liquid, CBI
Odour
Slight, aromatic odor
Boiling point
644 °F at 760 mmHg (NTP, 1992) · 340 °C
Melting point
-31 °F (NTP, 1992) · -35 °C
Solubility
less than 1 mg/mL at 68 °F (NTP, 1992) · More soluble in /perspiration/ than in water & increased solubility with pH rise
Density
1.049 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.0459 and 1.0465 at 20 °C
Stability
Stable under recommended storage conditions.
Odour threshold
0.26~1.47 ㎎/㎥
Melting/freezing point
-35 ℃
Flash point
186.5 ℃
Flammability (solid, gas)
not flammable
Upper/lower flammability or explosive limits
2.5 / 0.5 % (235℃)
Vapour pressure
9.7 mPa
Water solubility
11.4 ㎎/ℓ(25℃, pH: 6.41~6.67)
Vapour density
9.6
Relative density
1.05 (20℃)
n-Octanol/water partition coefficient (Kow)
4.46 (30℃, pH: 5~8)
Auto-ignition temperature
390 ℃
Viscosity
20.3 mPa S
Molecular weight
278.35

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 34 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Plasticizer21
  • Fragrance4
  • Solvent4
  • Deodorizer1
  • Degradant/impurity (EPA)1
  • Adhesion/cohesion promoter1
  • Processing aids not otherwise specified1
  • Absorbent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 3 eye studies are on record.

Classed as low7

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies
  • Not classified
    Skin Irritation · Screening
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • Category 1
    Skin Sensitization · Screening
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
  • Not classified
    Eye Irritation · Screening
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
  • Category 6.4A (Category 2A)
    Eye Irritation · Read Across

Source: US EPA CompTox dashboard

Related literature

Linked databases 27

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