Dichlorophene can cause developmental toxicity according to The Environmental Protection Agency (EPA).
Definition
Dichlorophene can cause developmental toxicity according to The Environmental Protection Agency (EPA).
Source: PubChem
US FDA substance register · UNII T1J0JOU64O · registered name DICHLOROPHEN · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Japan · Taiwan
- Restricted or banned
- Japan · South Korea · Taiwan
- Restricted
- United Kingdom
Source: Japan Standards for Cosmetics · Taiwan FDA cosmetic ingredients · MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Maximum concentration permitted at final product : 0.5%
- Use conditions and warnings that must appear on the label : It contains dichlorophen
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.5%
- Conditions of use and warning which must be printed on the labels : Contains dichlorophen
China
- Maximum concentration : 0.5%
European Union
- Maximum concentration in ready for use preparation : 0.5%
- Wording of conditions of use and warnings : Contains Dichlorophen
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 11 · maximum concentration 0.5%
Restriction III/11
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of Dichlorophene and Chlorophene
CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 97-23-4
- EC No.EU chemical inventory number
- 202-567-1
- DTXSIDUS EPA chemical ID
- DTXSID6021824
- DTXCIDUS EPA compound ID
- DTXCID901824
- IUPAC
- 2,2'-Methylenebis(4-chlorophenol)
- Molecular formula
- C13H10Cl2O2
- Molecular weight
- 269.12 g/mol
Measured properties
- Appearance
- Dichlorophene appears as white slightly cream or light pink-colored powder. Melting point 177 °C. Slight phenolic odor and a saline phenolic taste. Moderately toxic. Used as a fungicide and bactericide. · White slightly cream or light pink-colored powder, [CAMEO]
- Odour
- Odorless
- Melting point
- 351 to 352 °F (NTP, 1992) · 177-178 °C
- Solubility
- less than 1 mg/mL at 72 °F (NTP, 1992) · Sparingly sol in toluene, 1 g sol in 1 g of 95% ethanol, in less than 1 g of ether, sol in methanol, isopropyl ether, petroleum ether, sol (with decomp) in alkaline aq solutions
- Stability
- Slowly oxidized in air. Acidic in reaction, and forms salts with aqueous alkalis. Photolysis in acidic solution in the absence of oxygen results in hydrolysis of one chlorine atom, to give the corresponding phenol, in the presence of oxygen, the corresponding benzoquinone is formed, the same products are formed at pH 9, together with 4-chloro-2,2'-methylenediphenol. · Slight volatility
- Dissociation constant
- pKa1 = 7.60, pKa2 = 11.6
- Melting/freezing point
- 177 ℃
- Vapour pressure
- 0.0000000000975 ㎜Hg (at 25℃)
- Water solubility
- 30 ㎎/ℓ (at 25℃)
- n-Octanol/water partition coefficient (Kow)
- 4.26
- Molecular weight
- 269.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide3
- Processing aids not otherwise specified1
- Deodorizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Not classified
Skin Irritation · Screening - Category 1
Skin Sensitization · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Category 1
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Titanium allergy as a likely cause of post‐reconstruction dermatitis of the breast · 2021
- Safety assessment of dichlorophene and chlorophene. · 2004
- Safety Assessment of Dichlorophene and Chlorophene1 · 2004
- Dichlorophene (G-4) allergy. · 1970
- Determination of Dichlorophene, Hexachlorophene, and 2,2/-Thiobis(4,6-Dichlorophenol) in Soap and Cosmetic Preparations · 1954
Linked databases 25
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- Japan Standards for Cosmetics
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese