Ethyl malonate is a dicarboxylic acid.
Definition
Ethyl malonate is a dicarboxylic acid.
Source: PubChem
US FDA substance register · UNII 53A58PA183 · registered name Diethyl malonate · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts and Esters
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 105-53-3
- EC No.EU chemical inventory number
- 203-305-9
- DTXSIDUS EPA chemical ID
- DTXSID7021863
- DTXCIDUS EPA compound ID
- DTXCID701863
- IUPAC
- Diethyl propanedioate
- Molecular formula
- C7H12O4
- Molecular weight
- 160.169 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Melting/freezing point
- -50 ℃
- Initial boiling point and range
- 199 ℃
- Flash point
- 90 ℃(c.c.)
- Flammability (solid, gas)
- combustible
- Upper/lower flammability or explosive limits
- 0.8 / 12.8 %
- Vapour pressure
- 0.269 ㎜Hg(@ 25 ℃)
- Water solubility
- 23200 ㎎/ℓ(@ 37 ℃)
- Vapour density
- 5.52
- Relative density
- 1.055 (@ 20 ℃)
- n-Octanol/water partition coefficient (Kow)
- 0.96
- Auto-ignition temperature
- 435 ℃
- Molecular weight
- 160.17
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 154 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance143
- Flavouring and nutrient3
- Intermediate3
- Solvent3
- Processing aids not otherwise specified1
- No specific technical function1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 2A
Eye Irritation · Screening - Moderate or Mild Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
Source: US EPA CompTox dashboard
Related literature
- Evaluation of absorbent materials for use as ad hoc dry decontaminants during mass casualty incidents as part of the UK’s Initial Operational Response (IOR) · 2017
- Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species · 2012
- Cutaneous metabolism during in vitro percutaneous absorption · 2001
- Distribution and fate of diethyl malonate and diisopropyl fluorophosphate on pig skin in vitro. · 1988
- Evaluation of diethyl malonate as a simulant for 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) in shower decontamination of the skin. · 1984
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
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