Diethylamine is a secondary aliphatic amine where both N-substituents are ethyl.
定义
Diethylamine is a secondary aliphatic amine where both N-substituents are ethyl. It is a conjugate base of a diethylammonium.
来源: PubChem
美国FDA 物质登记 · UNII B035PIS86W · 登记名称 Diethylamine · 单一化学物质
化妆品中的作用
为产品增添香味PERFUMING登记为香料组成物质(并非表示其增香)FRAGRANCE稳定 pHBUFFERING
安全与法规参考
- 禁用
- 韩国 · 中国
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Restriction II/411 · Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
DIETHYLAMINEINCI다이에틸아민韩国标示名称(食药处标准名)Ethanamine, N-ethyl-同义名
- CAS No.化学物质登记号
- 109-89-7
- EC No.欧盟化学品目录编号
- 203-716-3
- DTXSID美国EPA化学品编号
- DTXSID6021909
- DTXCID美国EPA化合物编号
- DTXCID501909
- IUPAC
- N-Ethylethanamine
- 分子式
- C4H11N
- 分子量
- 73.139 g/mol
实测物性
- 性状
- Diethylamine appears as a clear colorless liquid with an ammonia-like odor. Density 5.9 lb / gal. Flash point -15 °F. A respiratory irritant. Corrosive to the eyes and skin. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. · Liquid
- 气味
- Fishy, ammonia-like odor
- 沸点
- 131.9 °F at 760 mmHg (NTP, 1992) · 55.5 °C
- 熔点
- -58 °F (NTP, 1992) · -50 °C
- 溶解性
- greater than or equal to 100 mg/mL at 63 °F (NTP, 1992) · In water, infinitely soluble /1X10+6 mg/L/ at 25 °C
- 密度
- 0.708 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.7056 g/cu cm at 20 °C
- 稳定性
- Stable under recommended storage conditions.
- 颜色
- 无色
- 嗅觉阈值
- 0.14 ppm
- 熔点/凝固点
- -50 ℃
- 初沸点和沸程
- 55.5 ℃(at 101.325Pa)
- 闪点
- -26 ℃
- 蒸发速率
- 16.9
- 燃烧或爆炸范围上限/下限
- 10.1 / 1.8 %
- 蒸气压
- 25.9 ㎪ (20℃)
- 溶解度
- 100 g/100㎖ (25℃)
- 蒸气密度
- 2.5
- 比重
- 0.7
- 正辛醇/水分配系数(Kow)
- 0.58
- 自燃温度
- 312 ℃
- 黏度
- 0.571 (25℃)
- 分子量
- 73.14
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 8 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Intermediate2
- Catalyst1
- Monomers1
- Flavouring and nutrient1
- pH regulating agent1
- Fragrance1
- Deodorizer1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 9 项、眼部试验 3 项。
归类为刺激性高1 项
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 12 项试验
- Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Category 8.2B (Category 1B)
Skin Irritation · Read Across - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to other guideline: Gad, S.C., Toxicol. Appl. Pharmacol., 1984, 93 - 114 - Category 1
Skin Irritation · Screening - Skin Corr. 1A
Skin Irritation · Authoritative - Classification not possible
Skin Sensitization · Screening - Ambiguous
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
来源: 美国EPA CompTox
相关文献
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- Formulation development, in vitro and in vivo assessment of Diclofenac diethylamine nanosponge loaded topical formulation · 2022
- Comparative Pharmacokinetic Studies of Marketed and Microsponges Gel Loaded with Diclofenac Diethylamine in Rabbits · 2021