Definition
US FDA substance register · UNII YAI66YDY1C · registered name DIETHYLENE GLYCOL DIBENZOATE · single chemical substance
Cosmetic roles
Keeps a film flexiblePLASTICISERSoftens hairHAIR CONDITIONINGMakes skin soft and smoothSKIN CONDITIONING - EMOLLIENT
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
DIETHYLENE GLYCOL DIBENZOATEINCI다이에틸렌글라이콜다이벤조에이트Korean label name (MFDS standard)Ethanol, 2,2'-oxybis-, dibenzoateSynonym
- CAS No.chemical registry number
- 120-55-8
- EC No.EU chemical inventory number
- 204-407-6
- DTXSIDUS EPA chemical ID
- DTXSID0026967
- DTXCIDUS EPA compound ID
- DTXCID006967
- IUPAC
- Oxydi(ethane-2,1-diyl) dibenzoate
- Molecular formula
- C18H18O5
- Molecular weight
- 314.337 g/mol
Measured properties
- Appearance
- Liquid · Liquid, [Hawley] Solid, mp = 28 deg C, [ICSC] Liquid, mp = -28 deg C, [HSDB] 89.9% Diethylene glycol, dibenzoate freezing point = 24 deg C, [eChemPortal: HPVIS] Colorless to straw-colored viscous liquid, mp ~ 16 deg C, [MSDSonline]
- Boiling point
- 225-227 °C @ 3 MM HG · at 0.7kPa: 236 °C
- Melting point
- -28 °C · 28 °C
- Solubility
- SOL IN WATER · Solubility in water: miscible
- Density
- 1.2 @ 68 °F (20 °C) · Relative density (water = 1): 1.2
- Viscosity
- 110 mPa.s @ 20 °C · 110 cP (20 C)
- Melting/freezing point
- 34 ℃
- Initial boiling point and range
- 279~281 ℃
- Flash point
- 232 ℃
- Vapour pressure
- 0.00005 ㎜Hg (69 C)
- Vapour density
- 9.38 ()
- Relative density
- 1.1701 ()
- n-Octanol/water partition coefficient (Kow)
- 3.04 (est.)
- Molecular weight
- 314.34
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 27 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Plasticizer11
- Binder6
- Softener and conditioner6
- Adhesion/cohesion promoter2
- Processing aids not otherwise specified1
- UV stabilizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 2 eye studies are on record.
Classed as low2
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Japanese Ministry of Agriculture Forestry and Fisheries Requirements for Safety Evaluation of Agricultural Chemicals and Testing Guidelines for Toxicology Studies, Acute Dermal Irritation Study 59 NohSan No. 4200 Agricultural Production Bureau Jan 28 1985 according to EPA OTS 798.4470 (Acute Dermal Irritation) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EPA OTS 798.4100 (Skin Sensitisation) according to other guideline: Notification Yakushin 1 No. 24 11 September 1989, Pharmaceutical Affairs Bureau, MOHW "Skin Sensitization Tests". according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: JMAFF, Requirements for Safety Evaluation of Agricultural Chemicals and Testing Guidelines for Toxicology Studies, Primary Eye Irritation Study, 59 NohSan No 4200, Agricultural Production Bureau, January 28, 1985. according to EPA OTS 798.4500 (Acute Eye Irritation) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) Note - study report refers to the guideline as number 404 "Acute Eye Irritation / corrosion", adopted 24 February 1987. according to
Source: US EPA CompTox dashboard
Related literature
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata