Ingredient Dictionary

DIHYDROCOUMARIN

3,4-dihydrocoumarin is a chromanone that is the 3,4-dihydro derivative of coumarin.

Definition

3,4-dihydrocoumarin is a chromanone that is the 3,4-dihydro derivative of coumarin. It has a role as a plant metabolite. It is functionally related to a coumarin.

Source: PubChem

US FDA substance register · UNII NM5K1Y1BT2 · registered name BENZODIHYDROPYRONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEGives the product a scentPERFUMING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · United Kingdom
Restricted or banned: Argentina · ASEAN · Brazil · China · European Union · South Korea
Restricted: International fragrance standard (IFRA)

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS) · Health Canada Cosmetic Ingredient Hotlist · IFRA fragrance standards

Canada

Conditions of Use by product type : (a) Leave-on products (b) Rinse-off products
Maximum Concentration Permitted : ((a) 0.035% (b) 3.5%

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 427

Source: EU prohibited substances (Annex II)

Restriction II/427

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

DIHYDROCOUMARININCI다이하이드로쿠마린Korean label name (MFDS standard)2H-1-Benzopyran-2-one, 3,4-dihydro-Synonym

CAS No.chemical registry number: 119-84-6
EC No.EU chemical inventory number: 204-354-9
DTXSIDUS EPA chemical ID: DTXSID2020474
DTXCIDUS EPA compound ID: DTXCID00474

IUPAC: 3,4-Dihydro-2H-1-benzopyran-2-one
Molecular formula: C9H8O2
Molecular weight: 148.161 g/mol

Measured properties

Appearance: 3,4-dihydrocoumarin is a white to pale yellow clear oily liquid with a sweet odor. Solidifies around room temperature. (NTP, 1992) · White to light yellow liquid, Colorless solid, [HSDB] Low melting solid, mp = 24-26 deg C, [MSDSonline]
Odour: Herbal · Odor similar to coumarin at room temp or reminiscent of nitrobenzene at higher temp.
Boiling point: 522 °F at 760 mmHg (NTP, 1992) · 272 °C
Melting point: 77 °F (NTP, 1992) · 25 °C
Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) · Slightly soluble in ether and carbon tetrachloride
Density: 1.169 at 64 °F (NTP, 1992) - Denser than water, will sink · 1.169 @ 18 °C
Colour: colourless
Melting/freezing point: 25 ℃
Initial boiling point and range: 272 ℃
Flash point: 130 ℃
Flammability (solid, gas): flammable
Water solubility: 3000 ㎎/ℓ (@ 37 ℃)
Vapour density: 5.11
Relative density: 1.169 (@ 18 ℃)
n-Octanol/water partition coefficient (Kow): 0.97 (est.)
Molecular weight: 148.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 7 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient3
Fragrance3
Deodorizer1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Category 6.5B (Category 1)
Skin Sensitization · Read Across
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) Magnusson and Kligman guinea pig maximisation test
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) equivalent or similar to