Ingredient Dictionary

DIHYDROXYBIPHENYL

Biphenyl-4,4'-diol is a member of the class of hydroxybiphenyls that is biphenyl with hydroxy groups at positions 4 and 4'.

Definition

Biphenyl-4,4'-diol is a member of the class of hydroxybiphenyls that is biphenyl with hydroxy groups at positions 4 and 4'. It derives from a hydride of a biphenyl.

Source: PubChem

US FDA substance register · UNII R8994A0904 · registered name 4,4'-BIPHENYLDIOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Protects skin from outside irritantsSKIN PROTECTINGLightens hair or skinBLEACHING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

DIHYDROXYBIPHENYLINCI[1,1'-Biphenyl]-4,4'-diolSynonym

CAS No.chemical registry number: 92-88-6
EC No.EU chemical inventory number: 202-200-5
DTXSIDUS EPA chemical ID: DTXSID1029120
DTXCIDUS EPA compound ID: DTXCID709120

IUPAC: [1,1'-Biphenyl]-4,4'-diol
Molecular formula: C12H10O2
Molecular weight: 186.21 g/mol

Measured properties

Appearance: Dry Powder, Other Solid · Off-white, light beige, or light gray odorless powder, [Acros Organics MSDS]
Odour: odourless
Melting/freezing point: 260 ℃
Relative density: 1.37 (g/cm3)
n-Octanol/water partition coefficient (Kow): 2.8 (NITE)
Molecular weight: 186.21

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Humectant1
Intermediate1
Bleaching agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 3 eye studies are on record.

Classed as highly irritating1Classed as low1

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

SkinSens1
Skin Sensitization · QSAR Predicted
Classification not possible
Skin Sensitization · Screening
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
Classification not possible
Skin Irritation · Screening
Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: OECD Guideline 439 In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method (22 July 2010); Commission Regulation (EC) No. 761/2009 amending Regulation (EC) No. 440/2008, B.46 In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test according to
Classification not possible
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline No. 437 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to