Ingredient Dictionary

DIHYDROXYINDOLE

5,6-dihydroxyindole is a dihydroxyindole.

Definition

5,6-dihydroxyindole is a dihydroxyindole. It has a role as a mouse metabolite.

Source: PubChem

US FDA substance register · UNII Z3OC8499KG · registered name DIHYDROXYINDOLE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Restricted: Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Maximum authorised concentration in the finished cosmetic product : (b) 0.5%
Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5% (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows

European Union

Product Type, body parts : (a) Hair dye substance in oxidative hair dye products
Other : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,5%
Wording of conditions of use and warnings : To be printed on the label: Hair colorants can cause severe allergic reactions.

Source: MFDS (Korea) cosmetic regulatory information

EU Cosmetics Regulation, Annex III (restricted substances), entry 207 · applies to (a) Hair dye substance in oxidative hair dye products

Source: EU restricted substances (Annex III)

Restriction Annex III/207 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on Dihydroxyindole

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ジヒドロキシインドール: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

DIHYDROXYINDOLEINCI다이하이드록시인돌Korean label name (MFDS standard)ジヒドロキシインドールJapanese labelling name

CAS No.chemical registry number: 3131-52-0
EC No.EU chemical inventory number: 412-130-9
DTXSIDUS EPA chemical ID: DTXSID20185242
DTXCIDUS EPA compound ID: DTXCID30107733

IUPAC: 1H-Indole-5,6-diol
Molecular formula: C8H7NO2
Molecular weight: 149.149 g/mol

Measured properties

Appearance: Solid · solid
Melting/freezing point: 123 ℃
Initial boiling point and range: 411 ℃(est.)
Flash point: 202.5 ℃(est.)
Vapour pressure: 2.4E-7 ㎜Hg (est.)
Water solubility: 123000 ㎎/ℓ (20℃)
Relative density: 1.28
Auto-ignition temperature: 348 ℃
Molecular weight: 149.15

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye1

Source: US EPA CompTox dashboard