Diisopropanolamine is a secondary amino compound that is diethanolamine substituted by methyl groups at positions 1 and 1'.
Definition
Diisopropanolamine is a secondary amino compound that is diethanolamine substituted by methyl groups at positions 1 and 1'. It is a versatile chemical used in a variety of personal care, cosmetic and industrial products. It has a role as a surfactant, a buffer and an emulsifier. It is an aminodiol, a secondary alcohol and a secondary amino compound. It is functionally related to a 1-aminopropan-2-ol.
Source: PubChem
US FDA substance register · UNII 0W44HYL8T5 · registered name DIISOPROPANOLAMINE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/411
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine
Reviewed by CIR: Extended Re-review Summary: Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ＤＩＰＡ: 本品は、次の化学式で表されるアルカノールアミンである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 110-97-4
- EC No.EU chemical inventory number
- 203-820-9
- DTXSIDUS EPA chemical ID
- DTXSID8020179
- DTXCIDUS EPA compound ID
- DTXCID20179
- IUPAC
- 1,1'-Azanediyldi(propan-2-ol)
- Molecular formula
- C6H15NO2
- Molecular weight
- 133.191 g/mol
Measured properties
- Melting/freezing point
- 42 / 45 ℃
- Initial boiling point and range
- 249~250 ℃
- Flash point
- 127 ℃(o.c.)
- Evaporation rate
- (&, lt, 1)
- Upper/lower flammability or explosive limits
- 5.4 / 1.1 %
- Vapour pressure
- 0.02 ㎜Hg (42℃)
- Water solubility
- 87 g/100㎖
- Vapour density
- 4.59
- Relative density
- 0.99
- n-Octanol/water partition coefficient (Kow)
- -0.82
- Auto-ignition temperature
- 374 ℃
- Molecular weight
- 133.19
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 39 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Chelating agent13
- pH regulating agent12
- Hydraulic fluids3
- Emulsifier2
- Intermediate2
- Processing aids not otherwise specified1
- Surfactant (surface active agent)1
- Cleaning agent1
4 other uses
- Solvent1
- Stabilizing agent1
- Brightener1
- Lubricating agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 5 eye studies are on record.
The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not classified
Skin Sensitization · Screening - Category 1
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Eye Irrit. 2
Eye Irritation · Authoritative - Category 2A
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- 3: Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine · 1987
- Evaluation of in Vitro and in Vivo Transdermal Absorption of Solifenacin Succinate. · 2019
- Effects of diisopropanolamine and isostearic acid, an ionic liquid, on skin permeation enhancement of ibuprofen and lidocaine in vitro · 2009
- Preliminary evaluation of interactions between selected alcoholamines and model skin sebum components. · 2006
- Influence of combinations of enhancers on skin permeation of meloxicam · 2006
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese