Diisopropyl adipate is an isopropyl ester and a fatty acid ester.
How much products actually contain
No product states its amount yet.
Of the products containing it, 39 list it before the 1% line and 12 after it (usually 1% or less).
Products using this ingredient
12 of 51 confirmed · likeliest to carry enough first · See all 51
Sun BumSun Bum Kids SPF 50 Clear Sunscreen Lotion
Glow RecipeGlow Recipe Watermelon Glow Dew Shield SPF 30
OribeOribe Gold Lust Dry Heat Protection Spray
AvèneSun Care for Kids 250ml
Elizabeth ArdenElizabeth Arden Retinol + HPR Ceramide Rapid Skin-Renewing Water Cream
MilaniMilani Make It Last Microfine Mist Setting Spray
DermalogicaDermalogica skinperfect primer spf30
Elizabeth ArdenElizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum
TonyMolyMild Apricot Tone-Up Sun Cream
ILLIYOONILLIYOON Ceramide Ato Concentrate Cream
ROVECTINROVECTIN Calming Lotus Sunscreen SPF 50+, PA ++++
Supergoop!Supergoop! Unseen Sunscreen Stick SPF 40
Definition
Diisopropyl adipate is an isopropyl ester and a fatty acid ester.
Source: PubChem
US FDA substance register · UNII P7E6YFV72X · registered name DIISOPROPYL ADIPATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2002/2003
Reviewed by CIR: Final Report on the Safety Assessment of Dioctyl Adipate and Diisopropyl Adipate
Reviewed by CIR: Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts and Esters
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アジピン酸ジイソプロピル: 本品は、アジピン酸（＊）とイソプロパノール（＊）のジエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 6938-94-9
- EC No.EU chemical inventory number
- 230-072-0
- DTXSIDUS EPA chemical ID
- DTXSID5027641
- DTXCIDUS EPA compound ID
- DTXCID507641
- IUPAC
- Di(propan-2-yl) hexanedioate
- Molecular formula
- C12H22O4
- Molecular weight
- 230.304 g/mol
Measured properties
- Appearance
- Liquid · Clear colourless liquid, Light alcoholic aroma
- Boiling point
- 251.00 to 253.00 °C. @ 760.00 mm Hg · 251-253 °C
- Melting point
- -1 °C
- Solubility
- Practically insoluble or insoluble in water · Soluble (in ethanol)
- Density
- 0.963-0.968 (20 °C)
- Melting/freezing point
- -1.1 ℃
- Molecular weight
- 230.31 (est.)
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 23 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner6
- Plasticizer4
- Fragrance4
- Solvent4
- Deodorizer2
- Flavouring and nutrient1
- Lubricating agent1
- Anti-adhesive/cohesive1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 3 eye studies are on record.
The studies disagree (the most common conclusion covers 14%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) adopted in 1992 according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Draize test according to - Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Whole body immersion test according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: according to
Source: US EPA CompTox dashboard
Related literature
- Emulsion stability of β-glucans isolated from wine lees in oilbased systems · 2026
- Investigation of the Compatibility of the Skin PAMPA Model with Topical Formulation and Acceptor Media Additives Using Different Assay Setups · 2019
- An Aliphatic Ester Diisopropyl Sebacate Exhibited an Adjuvant Effect on Fluorescein Isothiocyanate-Induced Contact Hypersensitivity Mouse Models. · 2018
- Adjuvant Effect of an Alternative Plasticizer, Diisopropyl Adipate, on a Contact Hypersensitivity Mouse Model: Link with Sensory Ion Channel TRPA1 Activation. · 2015
- Effect of Fatty Acid Diesters on Permeation of Anti-Inflammatory Drugs Through Rat Skin · 2002
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4 5
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata