What is this ingredient?

미국 FDA 물질 등록 · UNII BR9JLI40NO · 등록명 Diisopropylamine · 단일 화학물질

All ingredients

Ingredient Dictionary

DIISOPROPYLAMINE

Definition

US FDA substance register · UNII BR9JLI40NO · registered name Diisopropylamine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERING

Safety & regulatory references

Banned: China · South Korea

Source: MFDS (Korea) cosmetic regulatory information

Korea’s toxic-substance GHS classification: Danger · H314 (category 1A) · H331 (category 3) · H302 (category 4) · +1 more

Source: Korea toxic substances GHS register (NIER)

Restriction II/411

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Diisopropylamine

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

DIISOPROPYLAMINEINCI다이아이소프로필아민Korean label name (MFDS standard)2-Propanamine, N-(1-methylethyl)-Synonym

CAS No.chemical registry number: 108-18-9
EC No.EU chemical inventory number: 203-558-5
DTXSIDUS EPA chemical ID: DTXSID9025085
DTXCIDUS EPA compound ID: DTXCID905085

IUPAC: N-(Propan-2-yl)propan-2-amine
Molecular formula: C6H15N
Molecular weight: 101.193 g/mol

Measured properties

Appearance: liquid
Colour: colourless
pH: 12
Melting/freezing point: -61 ℃
Initial boiling point and range: 84 ℃
Flash point: -13.45 ℃
Evaporation rate: 5.8
Upper/lower flammability or explosive limits: 7.1 / 0.8 %
Vapour pressure: 79.4 ㎜Hg (25℃)
Water solubility: 1.1X10+5 ㎎/ℓ (25℃)
Vapour density: 3.5
Relative density: 0.7169
n-Octanol/water partition coefficient (Kow): 0.4
Auto-ignition temperature: 295 ℃ (1007 hPa)
Decomposition temperature: -11000 (cal/g)
Viscosity: 0.4 (25℃)
Molecular weight: 101.19

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Intermediate2
Abrasive1
Solvent1
pH regulating agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

9 skin studies and 4 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 13 studies

Skin Corr. 1B
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Skin corrosion/irritation - Category 1
Skin Irritation · Screening
Category 1A
Skin Irritation · Screening
Category 8.2B (Category 1B)
Skin Irritation · Read Across
Skin Corr. 1B
Skin Irritation · Authoritative
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Eye Dam. 1
Eye Irritation · Screening
Category 1
Eye Irritation · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to