Ingredient Dictionary

DIMETHOXYDIGLYCOL

Diglyme is a polyether that is the dimethyl ether derivative of diethylene glycol.

Definition

Diglyme is a polyether that is the dimethyl ether derivative of diethylene glycol. It has a role as a xenobiotic, a solvent and an environmental contaminant. It is functionally related to a diethylene glycol.

Source: PubChem

US FDA substance register · UNII M4BH3X0MVZ · registered name Diethylene glycol dimethylether · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H226 (category 3) · H360 (category 1B)

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 676

Source: EU prohibited substances (Annex II)

Restriction II/676

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

DIMETHOXYDIGLYCOLINCI다이메톡시다이글라이콜Korean label name (MFDS standard)Ethane, 1,1'-oxybis[2-methoxy-Synonym

CAS No.chemical registry number: 111-96-6
EC No.EU chemical inventory number: 203-924-4
DTXSIDUS EPA chemical ID: DTXSID1024621
DTXCIDUS EPA compound ID: DTXCID604621

IUPAC: 1-Methoxy-2-(2-methoxyethoxy)ethane
Molecular formula: C6H14O3
Molecular weight: 134.175 g/mol

Measured properties

Appearance: Diethylene glycol dimethyl ether is a colorless watery liquid with a pleasant odor. Floats and mixes with water. (USCG, 1999) · Liquid
Odour: Mild odor
Boiling point: 321 to 324 °F at 760 mmHg, 241 °F at 200 mmHg, 167 °F at 35 mmHg, 68 °F at 3 mmHg (NTP, 1992) · boiling point equals 321 to 324 °F
Melting point: -90 °F (NTP, 1992) · -68 °C
Solubility: Miscible (NTP, 1992) · Miscible with alcohol, ether, hydrocarbon solvents
Density: 0.945 at 68 °F (USCG, 1999) - Less dense than water, will float · Sp gr: 0.9451 at 20 °C/20 °C
Viscosity: 1.089 cP at 20 °C · 1.089 cP
Melting/freezing point: -68 ℃
Initial boiling point and range: 162 ℃(760 ㎜Hg)
Flash point: 59 ℃
Vapour pressure: 0.6 hPa (20℃)
Water solubility: 940 g/ℓ
Vapour density: 0.94 g/㎤
Relative density: 0.9451 (20/20℃)
n-Octanol/water partition coefficient (Kow): -0.36 (log Pow, 25℃)
Auto-ignition temperature: 190 ℃ (1004 hPa)
Molecular weight: 134.17

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent3
Monomers2
Processing aids not otherwise specified1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 2 eye studies are on record.

Classed as low3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Not classified
Skin Irritation · Screening
Not classified
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to other guideline: according to method: s1500.41 Federal register 38, No. 187, 27.09.1973, p 27019. according to
Category 2B
Eye Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to other guideline: FDA Guideline, Register 38 No. 187, 27.09.1973, p 27019 according to