Definition
US FDA substance register · UNII 1I9VFA346P · registered name DIMETHYL GLUTARATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts and Esters
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name グルタル酸ジメチル: 本品は、グルタル酸とメチルアルコールのジエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 1119-40-0
- EC No.EU chemical inventory number
- 214-277-2
- EC No.EU chemical inventory number
- 906-170-0
- DTXSIDUS EPA chemical ID
- DTXSID3025122
- DTXCIDUS EPA compound ID
- DTXCID105122
- IUPAC
- Dimethyl pentanedioate
- Molecular formula
- C7H12O4
- Molecular weight
- 160.169 g/mol
Measured properties
- Appearance
- Dimethyl glutarate is a colorless liquid. (USCG, 1999) · Liquid, CBI
- Odour
- FAINT AGREEABLE ODOR
- Boiling point
- 199.4 to 203 °F at 13 mmHg (USCG, 1999) · 213.5-214 °C @ 752 MM HG, 93.5-94.5 °C @ 13 MM HG
- Melting point
- -42.5 °C
- Solubility
- VERY SOL IN ALC, ETHER
- Density
- 1.087 (USCG, 1999) - Denser than water, will sink · 1.0876 @ 20 °C/4 °C
- Colour
- colourless
- Melting/freezing point
- -42.5 ℃
- Initial boiling point and range
- 214 ℃(751mmHg)
- Flash point
- 103 ℃
- Upper/lower flammability or explosive limits
- 7.9 / 0.9 %
- Vapour pressure
- 0.18 ㎜Hg ((25 ℃))
- Water solubility
- 5900 ㎎/ℓ ((25 ℃))
- Vapour density
- 5.52 ()
- Relative density
- 1.0876
- n-Octanol/water partition coefficient (Kow)
- 0.62
- Auto-ignition temperature
- 365 ℃
- Viscosity
- 2.5 cSt (25.00 C)
- Molecular weight
- 160.17
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 150 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance104
- Solvent19
- Processing aids not otherwise specified4
- Viscosity modifier3
- Cleaning agent2
- Anti-static agent2
- Dispersing agent2
- Softener and conditioner2
11 other uses
- Adhesion/cohesion promoter2
- Diluent1
- Intermediate1
- Plasticizer1
- Binder1
- Thickening agent1
- Surface modifier1
- Soil amendments1
- Monomers1
- Lubricating agent1
- Solubility enhancer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 3 eye studies are on record.
The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Chinese