Definition
US FDA substance register · UNII 11JIB0YI93 · registered name DIMETHYL ITACONATE · single chemical substance
Dimethyl Itaconate is the organic compound that conforms to the formula
Cosmetic roles
Slows spoilage by oxygenANTIOXIDANTSkin conditioning not covered aboveSKIN CONDITIONING - MISCELLANEOUSProtects skin from outside irritantsSKIN PROTECTINGSoftens hairHAIR CONDITIONING
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
DIMETHYL ITACONATEINCI다이메틸이타코네이트Korean label name (MFDS standard)
- CAS No.chemical registry number
- 617-52-7
- EC No.EU chemical inventory number
- 210-519-6
- DTXSIDUS EPA chemical ID
- DTXSID80210701
- DTXCIDUS EPA compound ID
- DTXCID70133192
- IUPAC
- Dimethyl 2-methylidenebutanedioate
- Molecular formula
- C7H10O4
- Molecular weight
- 158.153 g/mol
Measured properties
- Melting/freezing point
- 38 ℃(EXP)
- Initial boiling point and range
- 208 ℃(EXP)
- Flash point
- 100 ℃(c.c)
- Water solubility
- 14030 ㎎/ℓ
- Relative density
- 1.1241 ( at 18℃)
- n-Octanol/water partition coefficient (Kow)
- 0.820 (est.)
- Molecular weight
- 158.152
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
Irritation and sensitisation studies
5 skin studies and 4 eye studies are on record.
Classed as highly irritating3Classed as moderate1
The study conclusions largely agree (75%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Severe Irritation
skin corrosion: in vitro / ex vivo · Screening · OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) adopted 22 July 2010 according to EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test) according to - Corrosive
skin corrosion: in vitro / ex vivo · Screening · EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test) Official Journal of the European Union No. L142; Amended by EC No. 640/2012 OJ No. L193, 20 July 2012 ( (EpiSkin model)) according to OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) adopted 26 July 2013 (EpiSkin model) according to - SkinSens1
Skin Sensitization · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) as at 2002 according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) as at 2008 according to EPA OPPTS 870.2600 (Skin Sensitisation) as at 2003 - Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FAMIC according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants) according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline no. 437: "Bovine corneal opacity and permeability (BCOP) test method for identifying ocular corrosives and severe irritants" (adopted September 07, 2009) according to - Moderate or Mild Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants) according to
Source: US EPA CompTox dashboard
Related literature
- Dimethyl itaconate suppresses dendritic cell and CD8+ T cell responses to halt vitiligo · 2025
- ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives · 2022
- Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata · 2022
- Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis · 2020
- Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis · 2020
Linked databases 14
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata