N,N-dimethyl-1-Dodecanamine is a tertiary amino compound.
- Korean limit
- 2.5%
Definition
N,N-dimethyl-1-Dodecanamine is a tertiary amino compound.
Source: PubChem
US FDA substance register · UNII 6V2OM30I1Z · registered name DIMETHYL LAURAMINE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- China · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Field of application and/or use : (a) Products without rinse. (b) Other products.
- Maximum concentration permitted at final product : (a) 2.5%
- Other limitations and requirements : a.- b.- . No use with nitrosating systems . -Pureza minimum 99% maximum -Tenor of secondary amines in raw materials 0.5%. Maximum nitrosamine -Tenor. 50 ug / kg -Envasar / keep in containers free of nitrites
ASEAN
- Field of application and/or use : (a) non-rinse-off products (b) other products
- Maximum authorised concentration in the finished cosmetic product : (a) 2.5%
- Other limitations and requirements : (a) (b): • Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content: 0.5% (applies to raw materials) • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers
European Union
- Product Type, body parts : (a) Leave-on products (b) Rinse-off products
- Maximum concentration in ready for use preparation : (a) 2.5%
- Other : (a) (b) - Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H302 (category 4) · H410 (category 1) · H400 (category 1) · +1 more
Restriction III/62
Source: EU CosIng ingredient list
Reviewed by CIR: Final Amended Safety Assessment of the Cosmetic Ingredient Review Expert Panel: Dimethyl Stearamine and Related Tertiary Aliphatic Amines as Used in Cosmetics (Dimethyl Stearamine, Dimethyl Lauramine, Dimethyl Myristamine, Dimethyl Pamitamine, Dimethyl Behenamine, Dimethyl Cocamine, Dimethyl Tallowamine, Dimethyl Hydrogenated Tallowamine, Dimethyl Soyamine)
Reviewed by CIR: Final Report on the Safety Assessment of Dimethyl Lauramine
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ジメチルラウラミン: 本品は、次の化学式で表される脂肪族３級アミンである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 112-18-5
- EC No.EU chemical inventory number
- 203-943-8
- EC No.EU chemical inventory number
- 266-922-2
- DTXSIDUS EPA chemical ID
- DTXSID1026906
- DTXCIDUS EPA compound ID
- DTXCID806906
- IUPAC
- N,N-Dimethyldodecan-1-amine
- Molecular formula
- C14H31N
- Molecular weight
- 213.409 g/mol
Measured properties
- Appearance
- N,n-dimethyldodecylamine appears as a clear yellow liquid with a fishlike odor. Insoluble in water and less dense than water. Hence floats on water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals. · Liquid, CBI
- Colour
- colourless
- Melting/freezing point
- -15 ℃
- Initial boiling point and range
- 260 ℃
- Flash point
- 149 ℃((PMCC))
- Vapour pressure
- 0.005 ㎜Hg
- Vapour density
- 7.4
- Relative density
- 0.79
- n-Octanol/water partition coefficient (Kow)
- 5.44
- Molecular weight
- 213.41
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 12 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Catalyst4
- Surfactant (surface active agent)4
- Intermediate2
- Anti-static agent1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Corrosive
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Classification not possible
Skin Sensitization · Screening - Category 1
Skin Irritation · Screening - SkinIrr2
Skin Irritation · QSAR Predicted - SkinSens1
Skin Sensitization · QSAR Predicted - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Category 8.2B (Category 1B)
Skin Irritation · Read Across - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 1
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata