What is this ingredient?

미국 FDA 물질 등록 · UNII 96J42P99ZA · 등록명 4,4-DIMETHYLOXAZOLIDINE · 단일 화학물질

All ingredients

Ingredient Dictionary

DIMETHYL OXAZOLIDINE

Korean limit: 0.05%

Definition

US FDA substance register · UNII 96J42P99ZA · registered name 4,4-DIMETHYLOXAZOLIDINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Dimethyl Oxazolidine is the heterocyclic compound that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Allowed preservative: United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.1%
Other limitations and requirements : The pH of the finished product should not be less than 6.

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.1%
Other limitations and requirements : The pH of the finished product must not be lower than 6

Taiwan

Maximum concentration : 0.1% (pH>6)

China

Maximum concentration : (a) 0.25%
(b)
Maximum concentration : 0.1%

South Korea

Maximum concentration : 0.05%

European Union

Maximum concentration in ready for use preparation : 0.1%
Other : pH > 6

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 45 · maximum concentration 0.1%

Source: EU allowed preservatives (Annex V)

Restriction V/45 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

DIMETHYL OXAZOLIDINEINCI디메칠옥사졸리딘Korean label name (MFDS standard)4,4-디메칠-1,3-옥사졸리딘(디메칠옥사졸리딘)Korean label name (MFDS standard)Oxazolidine, 4,4-dimethyl-Synonym

CAS No.chemical registry number: 51200-87-4
EC No.EU chemical inventory number: 257-048-2
DTXSIDUS EPA chemical ID: DTXSID0032314
DTXCIDUS EPA compound ID: DTXCID8012314

IUPAC: 4,4-Dimethyl-1,3-oxazolidine
Molecular formula: C5H11NO
Molecular weight: 101.149 g/mol

Measured properties

Appearance: CBI, Liquid · Colorless to slightly yellow liquid with a fishy odor, End-use formulations are soluble concentrate and liquid, [Reference #1] Pungent odor, [Dow MSDS]
Boiling point: 100.9 °C
Solubility: Miscible with water in all proportions · Miscible with methanol, ethanol, propanol and acetone
Density: Bulk density = 0.99 g/mL
Stability: Stable under recommended storage conditions.
Dissociation constant: pKa = 9.35
pH: 11
Initial boiling point and range: 100.9 ℃
Flash point: 49 ℃
Vapour pressure: 100 ㎜Hg (at 70 C)
Water solubility: 1000000 ㎎/ℓ (at 25 C , est.)
Relative density: 0.99 (g/cm3)
n-Octanol/water partition coefficient (Kow): -0.08 (est.)
Molecular weight: 101.15

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 16 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative9
Biocide5
Intermediate1
Solvent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across