Dimethyl phthalate is a methyl ester, a phthalate ester and a diester.
Definition
Dimethyl phthalate is a methyl ester, a phthalate ester and a diester.
Source: PubChem
US FDA substance register · UNII 08X7F5UDJM · registered name DIMETHYL PHTHALATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on Phthalates in Cosmetics Products
Source: EU CosIng ingredient list
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2002/2003
Reviewed by CIR: Final Report on the Safety Assessment of Dibutyl Phthalate, Dimethyl Phthalate, and Diethyl Phthalate
Reviewed by CIR: Re-evaluation: Dibutyl, Dimethyl and Diethyl Phthalate and Butyl Benzyl Phthalate
CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Amended Safety Assessment of Dibutyl Phthalate,Diethyl Phthalate, and Dimethyl Phthalate as Used in Cosmetics (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name フタル酸ジメチル: 本品は、フタル酸とメタノールのジエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 131-11-3
- EC No.EU chemical inventory number
- 205-011-6
- DTXSIDUS EPA chemical ID
- DTXSID3022455
- DTXCIDUS EPA compound ID
- DTXCID502455
- IUPAC
- Dimethyl benzene-1,2-dicarboxylate
- Molecular formula
- C10H10O4
- Molecular weight
- 194.186 g/mol
Measured properties
- Appearance
- Dimethyl phthalate appears as a water-white liquid without significant odor. Denser than water and insoluble in water. Hence sinks in water. Flash point 300 °F. Eye contact may produce severe irritation and direct skin contact may produce mild irritation. Used in the manufacture of a variety of products including plastics, insect repellents, safety glass, and lacquer coatings. · Liquid, CBI, Other Solid
- Odour
- Slight aromatic odor
- Boiling point
- 542.7 °F at 760 mmHg (NTP, 1992) · 283.7 °C at 760 mm Hg
- Melting point
- 32 °F (NTP, 1992) · 5.5 °C
- Solubility
- less than 1 mg/mL at 68 °F (NTP, 1992) · In water, 4,000 mg/L at 25 °C
- Density
- 1.1905 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.196 at 15.6 °C/15.6 °C, 1.1940 at 20 °C/20 °C, 1.189 at 25 °C/25 °C
- Stability
- Stable under recommended storage conditions.
- Viscosity
- 17.2 cP at 25 °C · 17.2 (25℃)
- Melting/freezing point
- 5.5 ℃
- Initial boiling point and range
- 284 ℃
- Flash point
- 146 ℃(c.c.)
- Upper/lower flammability or explosive limits
- 8 / 0.9 %
- Vapour pressure
- 399.033 ㎜Hg (20℃)
- Water solubility
- 0.4 g/100㎖ (25℃)
- Vapour density
- 6.69
- Relative density
- 1.19
- n-Octanol/water partition coefficient (Kow)
- 1.795
- Auto-ignition temperature
- 490 ℃
- Decomposition temperature
- -119.7 (kg-cal/mole )
- Molecular weight
- 194.185
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 27 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Plasticizer9
- Processing aids not otherwise specified6
- Solvent3
- Catalyst2
- Corrosion inhibitor2
- Deodorizer1
- Intermediate1
- Hardener1
2 other uses
- Fragrance1
- Film former1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to EPA OPPTS 870.2600 (Skin Sensitisation) - Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 2B
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Permeability of Dimethyl Phthalate Through Human Skin Models – Health Risk Assessment · 2023
- AN ASSESSMENTOF PHTHALATES IN COSMETIC PRODUCTS BY DISPERSIVE LIQUID-LIQUID EXTRACTION METHOD USING HPLCAND LC-MS/MS · 2021
- Mutagenicity and metabolism of dimethyl phthalate and its binding to epidermal and hepatic macromolecules. · 1991
- Defective UiO-67 for enhanced adsorption of dimethyl phthalate and phthalic acid · 2020
- 7 Final Report on the Safety Assessment of Dibutyl Phthalate, Dimethyl Phthalate, and Diethyl Phthalate · 1985
Linked databases 22
- AICIS inventory notices (Australia)
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4 5 6
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese