Ingredient Dictionary

DIMETHYL SUCCINATE

Dimethyl succinate is a fatty acid methyl ester.

Definition

Dimethyl succinate is a fatty acid methyl ester.

Source: PubChem

US FDA substance register · UNII 914I2127JR · registered name DIMETHYL SUCCINATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Makes skin soft and smoothSKIN CONDITIONING - EMOLLIENTKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEBase that dissolves other ingredientsSOLVENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts and Esters

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name コハク酸ジメチル: 本品は、コハク酸（＊）とメチルアルコールのジエステルであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

DIMETHYL SUCCINATEINCI다이메틸석시네이트Korean label name (MFDS standard)Butanedioic acid, dimethyl esterSynonymコハク酸ジメチルJapanese labelling name

CAS No.chemical registry number: 106-65-0
EC No.EU chemical inventory number: 203-419-9
DTXSIDUS EPA chemical ID: DTXSID5025152
DTXCIDUS EPA compound ID: DTXCID005152

IUPAC: Dimethyl butanedioate
Molecular formula: C6H10O4
Molecular weight: 146.142 g/mol

Measured properties

Appearance: Dimethyl succinate is a colorless liquid. (USCG, 1999) · CBI, Liquid
Odour: PLEASANT, ETHEREAL, WINEY ODOR
Boiling point: 385.5 °F at 760 mmHg (NTP, 1992) · 195.3 °C @ 760 MM HG
Melting point: 67.1 °F (NTP, 1992) · 19.5 °C
Solubility: greater than or equal to 100 mg/mL at 73 °F (NTP, 1992) · SOL IN 120 PARTS WATER, 35 PARTS ALC
Density: 1.117 (USCG, 1999) - Denser than water, will sink · 1.1202 @ 18 °C/4 °C
Colour: colourless
Melting/freezing point: 19 ℃
Initial boiling point and range: 190~196 ℃
Flash point: 85 ℃
Upper/lower flammability or explosive limits: 8.5 / 1.0 %
Vapour pressure: 0.41 ㎜Hg (at 25℃)
Water solubility: 25000 ㎎/ℓ
Vapour density: 5.04 ()
Relative density: 1.117-1.1198
n-Octanol/water partition coefficient (Kow): 0.35
Auto-ignition temperature: 365 ℃
Viscosity: 2.82 cP (20 C)
Molecular weight: 146.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 55 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent19
Softener and conditioner8
Processing aids not otherwise specified4
Fragrance3
Film former3
Flavouring and nutrient2
Intermediate2
Cleaning agent2

9 other uses

Dispersing agent2
Pigment2
Deodorizer2
Surface modifier1
Solubility enhancer1
Viscosity modifier1
Monomers1
Thickening agent1
No specific technical function1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 4 eye studies are on record.

Classed as low3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Not classified
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 2B
Eye Irritation · Screening