Definition
US FDA substance register · UNII O0V97PV2G1 · registered name 2-(N,N-DIMETHYLAMINO)ETHYL METHACRYLATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name メタクリル酸ジメチルアミノエチル: 本品は、次の化学式で表される脂肪族エステルアミンである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 2867-47-2
- EC No.EU chemical inventory number
- 220-688-8
- DTXSIDUS EPA chemical ID
- DTXSID1027504
- DTXCIDUS EPA compound ID
- DTXCID307504
- IUPAC
- 2-(Dimethylamino)ethyl 2-methylprop-2-enoate
- Molecular formula
- C8H15NO2
- Molecular weight
- 157.213 g/mol
Measured properties
- Appearance
- 2-dimethylaminoethyl methacrylate appears as a clear colorless liquid. Less dense than water and insoluble in water. Vapors heavier than air and corrosive to eyes and mucous membranes. May polymerize exothermically if heated or contaminated. If polymerization takes place inside a closed container, the container may rupture violently. Produces toxic oxides of nitrogen during combustion. Toxic by sk · Liquid
- Odour
- Amine-like
- Boiling point
- 186 °C
- Melting point
- -30 °C (freezing point) · -30 °C
- Solubility
- In water, 1000 g/L at 20 °C (study performed without adjustment of pH value) · Solubility in water, g/100ml at 25 °C: 10.6
- Density
- Specific gravity: 0.933 at 25 °C · Relative density (water = 1): 0.93
- Viscosity
- 1.34 mPa s at 25 °C
- Dissociation constant
- pKa = 8.44 at 25 °C
- Melting/freezing point
- -30 ℃
- Initial boiling point and range
- 186 ℃
- Flash point
- 68 ℃(C.C.)
- Upper/lower flammability or explosive limits
- - / 1.2 %
- Vapour pressure
- 0.11 ㎪ (25℃)
- Water solubility
- 10.6 g/100㎖ (25℃)
- Vapour density
- 5.4
- Relative density
- 0.93
- n-Octanol/water partition coefficient (Kow)
- 1.13
- Auto-ignition temperature
- 255 ℃
- Molecular weight
- 157.2
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Monomers2
- Intermediate1
- Film former1
- Viscosity modifier1
- Solvent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 10 studies
- Sh
Skin Sensitization · Authoritative - Skin Irrit. 2
Skin Irritation · Authoritative - Skin Sens. 1
Skin Sensitization · Authoritative - Not classified
Skin Sensitization · Screening - Category 1
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Category 1
Eye Irritation · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- pH‐responsive bionanocomposite pectin grafted with dimethylaminoethyl methacrylate and acrylic acid copolymer along with silver nanoparticles for breast cancer drug delivery · 2024
- Self-Crosslinking AuNPs Composite Hydrogel Bolus for Radiophotothermal Therapy. · 2024
- A gelatin-based ionogel with anti-swelling properties for underwater human physiological signal detection. · 2024
- Synthesis and in vitro cytotoxicity evaluation of star-shaped polymethacrylic conjugates with methotrexate or acitretin as potential antipsoriatic prodrugs. · 2019
- Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings. · 2017
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata