4-hydroxy-2,5-dimethylfuran-3-one is a member of the class of furans that is 2,5-dimethylfuran carrying additional oxo and hydroxy groups at positions 3 and 4 respectively.
How much products actually contain
No product states its amount yet.
Of the products containing it, 4 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
5 of 5 confirmed · likeliest to carry enough first
Definition
4-hydroxy-2,5-dimethylfuran-3-one is a member of the class of furans that is 2,5-dimethylfuran carrying additional oxo and hydroxy groups at positions 3 and 4 respectively. It has been found particularly in strawberries and other such fruits. It has a role as a flavouring agent, a fragrance and a plant metabolite. It is a member of furans, an enol and a cyclic ketone. It is a conjugate acid of a 4-hydroxy-2,5-dimethylfuran-3-olate.
Source: PubChem
US FDA substance register · UNII 20PI8YZP7A · registered name DIMETHYLHYDROXY FURANONE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- International fragrance standard (IFRA)
Source: IFRA fragrance standards
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ジメチルヒドロキシフラノン: 本品は、次の化学式で表される複素環式化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 3658-77-3
- EC No.EU chemical inventory number
- 222-908-8
- DTXSIDUS EPA chemical ID
- DTXSID0041517
- DTXCIDUS EPA compound ID
- DTXCID8021517
- IUPAC
- 4-Hydroxy-2,5-dimethylfuran-3(2H)-one
- Molecular formula
- C6H8O3
- Molecular weight
- 128.127 g/mol
Measured properties
- Appearance
- Liquid · Solid
- Odour
- Relatively weak, nonspecific odor, dilute solutions develop a pineapple, strawberry-like odor · Odor description at 0.01%: Sweet, slightly burnt brown caramellic, cotton candy with a savory nuance
- Boiling point
- 216 °C
- Melting point
- 77-79 °C · 77 - 78 °C
- Solubility
- In water, 0.315 g/mL at 25 °C · Soluble in oil and ethanol
- Stability
- Stable under recommended storage conditions.
- Dissociation constant
- pKa = 8.56 at 20 °C
- Colour
- Light yellow powder
- n-Octanol/water partition coefficient (Kow)
- 0.82
- Molecular weight
- 128.14
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 34 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance26
- Flavouring and nutrient4
- Deodorizer2
- Humectant2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Corrosive or Irritation Persists for > 21 days
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to
Source: US EPA CompTox dashboard
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese