Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
How much products actually contain
No product states its amount yet.
Of the products containing it, 1 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
1 of 1 confirmed · likeliest to carry enough first
Definition
Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a monomethoxyflavone, a rutinoside, a dihydroxyflavanone, a glycosyloxyflavone and a disaccharide derivative. It is functionally related to a diosmetin.
Source: PubChem
US FDA substance register · UNII 7QM776WJ5N · registered name Diosmin · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 520-27-4
- EC No.EU chemical inventory number
- 208-289-7
- DTXSIDUS EPA chemical ID
- DTXSID4045892
- DTXCIDUS EPA compound ID
- DTXCID2025892
- IUPAC
- 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
- Molecular formula
- C28H32O15
- Molecular weight
- 608.549 g/mol
Measured properties
- Boiling point
- 926.8±65.0
- Melting point
- 277-278
- Solubility
- 0.019 ± 0.005 mg/L
- Dissociation constant
- 6.10±0.40
- Appearance
- solid
- Odour
- odourless
- Melting/freezing point
- 275~277 ℃
- Vapour pressure
- 0 ㎩
- Water solubility
- 0.019 ㎎/ℓ (20 °C, pH:6.04-6.08)
- Relative density
- 1.485g/cm³
- n-Octanol/water partition coefficient (Kow)
- 0.14
- Molecular weight
- 608.5458
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to
Source: US EPA CompTox dashboard
Related literature
- Phlebotonics for venous insufficiency. · 2005
- Phlebotonics for venous insufficiency. · 2020
- [Diosmin-containing phlebotropic drugs in varicose eczema]. · 2019
- Phlebotonics for venous insufficiency. · 2016
- Ademetionine in Different Combination Regimens to Treat Rosacea: Results from a Randomized, Prospective Clinical Trial · 2016
Linked databases 16
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese