Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
产品中实际含有多少
暂无产品标示该成分含量。
含该成分的产品中，1 款将其列在 1% 线之前，0 款列在之后（通常不超过 1%）。
含有此成分的产品
已确认 1 款中的 1 款 · 按含量充足程度排序
定义
Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a monomethoxyflavone, a rutinoside, a dihydroxyflavanone, a glycosyloxyflavone and a disaccharide derivative. It is functionally related to a diosmetin.
来源: PubChem
美国FDA 物质登记 · UNII 7QM776WJ5N · 登记名称 Diosmin · 单一化学物质
化妆品中的作用
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 520-27-4
- EC No.欧盟化学品目录编号
- 208-289-7
- DTXSID美国EPA化学品编号
- DTXSID4045892
- DTXCID美国EPA化合物编号
- DTXCID2025892
- IUPAC
- 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
- 分子式
- C28H32O15
- 分子量
- 608.549 g/mol
实测物性
- 沸点
- 926.8±65.0
- 熔点
- 277-278
- 溶解性
- 0.019 ± 0.005 mg/L
- 解离常数
- 6.10±0.40
- 性状
- 固体
- 气味
- 无臭
- 熔点/凝固点
- 275~277 ℃
- 蒸气压
- 0 ㎩
- 溶解度
- 0.019 ㎎/ℓ (20 °C, pH:6.04-6.08)
- 比重
- 1.485g/cm³
- 正辛醇/水分配系数（Kow）
- 0.14
- 分子量
- 608.5458
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 1 项、眼部试验 2 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 3 项试验
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to
来源: 美国EPA CompTox
相关文献
- Phlebotonics for venous insufficiency. · 2005
- Phlebotonics for venous insufficiency. · 2020
- [Diosmin-containing phlebotropic drugs in varicose eczema]. · 2019
- Phlebotonics for venous insufficiency. · 2016
- Ademetionine in Different Combination Regimens to Treat Rosacea: Results from a Randomized, Prospective Clinical Trial · 2016