Ingredient Dictionary

DIOXOLANE

1,3-dioxolane is a cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively.

Definition

1,3-dioxolane is a cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively. It is a dioxolane and a cyclic acetal.

Source: PubChem

US FDA substance register · UNII Y57RBG19JL · registered name DIOXOLANE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ジオキソラン: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

DIOXOLANEINCI다이옥솔레인Korean label name (MFDS standard)ジオキソランJapanese labelling name

CAS No.chemical registry number: 646-06-0
EC No.EU chemical inventory number: 211-463-5
DTXSIDUS EPA chemical ID: DTXSID4027284
DTXCIDUS EPA compound ID: DTXCID107284

IUPAC: 1,3-Dioxolane
Molecular formula: C3H6O2
Molecular weight: 74.079 g/mol

Measured properties

Appearance: Dioxolane appears as a clear colorless liquid. Slightly denser than water. Vapors heavier than air. · Liquid
Boiling point: 78 °C · 78 °C @760 [mm Hg]
Melting point: -95 °C · -97.2 °C
Solubility: Soluble in ethanol, ether, acetone · Miscible in water
Density: 1.0600 at 20 °C/4 °C · A cyclic acetal, bulk density (wt/gal): 8.2 lb at 20 °C
Melting/freezing point: -95 ℃
Initial boiling point and range: 78 ℃
Flash point: 2 ℃
Vapour pressure: 79 ㎜Hg (20℃)
Water solubility: 100 g/100㎖ (25℃)
Vapour density: 2.6
Relative density: 1.06
n-Octanol/water partition coefficient (Kow): -0.37
Molecular weight: 74.08

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent6
Intermediate2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 3 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Not classified
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Category 6.3B (Category 3)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)
Ambiguous
skin irritation: in vivo · Screening · other guideline: 16 CFR 1500.41 according to
Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening
Category 2A
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across