Definition
US FDA substance register · UNII TC2D6JAD40 · registered name Diphenhydramine hydrochloride · single chemical substance
Diphenhydramine HCl is the amine salt that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · Japan · South Korea · Taiwan
Source: ASEAN Cosmetic Directive · MFDS (Korea) cosmetic regulatory information
Restriction II/339
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ジフェンヒドラミンＨＣｌ: 本品は、ジフェニルメトキシジメチルエタノールアミンの塩酸塩であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 147-24-0
- EC No.EU chemical inventory number
- 205-687-2
- DTXSIDUS EPA chemical ID
- DTXSID4020537
- DTXCIDUS EPA compound ID
- DTXCID20537
- IUPAC
- 2-(Diphenylmethoxy)-N,N-dimethylethan-1-amine--hydrogen chloride (1/1)
- Molecular formula
- C17H22ClNO
- Molecular weight
- 291.82 g/mol
Measured properties
- Appearance
- Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. (NTP, 1992)
- Melting point
- 331 to 338 °F (NTP, 1992)
- Solubility
- greater than or equal to 100 mg/mL at 70.7 °F (NTP, 1992) · >43.8 [ug/mL] (The mean of the results at pH 7.4)
- Colour
- white
- Odour
- odourless
- pH
- 5.5 ()
- Melting/freezing point
- 166~170 ℃
- Water solubility
- 1 g/㎖
- Relative density
- 1.2
- n-Octanol/water partition coefficient (Kow)
- 3.11
- Molecular weight
- 291.82
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 13 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Pharmaceutical (EPA)11
- Softener and conditioner2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Classification not possible
Skin Irritation · Screening - SkinSens1
Skin Sensitization · QSAR Predicted - Classification not possible
Skin Sensitization · Screening - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- DEMODICOSIS WITH TICKS INFESTATION AND BABESIOSIS IN A MIXED DOG · 2023
- Effects of Post-Therapy Changes on the Level of Immunoglobulin M in Dogs with Dermatitis · 2025
- MANAGEMENT OF NOTOEDRES CATI AND FELICOLA SUBROSTRATUS INFESTATION IN A MALE CAT · 2025
- PNEUMONIA AND DEMODICOSIS IN CROSSBREED POMERANIAN · 2024
- Assay of Diphenhydramine HCl in Syrup by High Performance Liquid Chromatography · 2023
Linked databases 17
- ASEAN Cosmetic Directive
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata