Etidronate disodium is an organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions.
Definition
Etidronate disodium is an organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions. It has a role as an antineoplastic agent, a chelator and a bone density conservation agent. It contains an etidronic acid(2-).
Source: PubChem
US FDA substance register · UNII M16PXG993G · registered name Etidronate Disodium · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- China · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Field of application and/or use : (a) Products for hair care (b) Soaps
- Maximum concentration permitted at final product : a.- 1.5% (calculated as Etidronic Acid) b.- 0.2% (calculated as Etidronic Acid)
ASEAN
- Field of application and/or use : (a) Hair-care (b) Soap
- Maximum authorised concentration in the finished cosmetic product : (a) 1.5% expressed as etidronic acid (b) 0.2% expressed as etidronic acid
European Union
- Product Type, body parts : (a) Hair product (b) Soap
- Maximum concentration in ready for use preparation : (a) 1.5% (as etidronic acid) (b) 0.2% (as etidronic acid)
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction III/53 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report: Safety Assessment of Etidronic Acid and Its Salts as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 7414-83-7
- EC No.EU chemical inventory number
- 231-025-7
- DTXSIDUS EPA chemical ID
- DTXSID1029671
- DTXCIDUS EPA compound ID
- DTXCID609671
- IUPAC
- Disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]
- Molecular formula
- C2H6Na2O7P2
- Molecular weight
- 249.99 g/mol
Measured properties
- Appearance
- solid
- Colour
- white
- Odour
- odourless
- Molecular weight
- 252.01
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Chelating agent1
Source: US EPA CompTox dashboard
Related literature
- [Congenital osteoma of the skin. Attempt at diphosphonate therapy]. · 1986
- HLA antigens in lichen scterosus et atro‐phicus · 1985
- Disodium etidronate therapy for dystrophic cutaneous calcification. · 1975
- Calcinosis universalis: a rare diagnosis. · 2005
- P28 Recalcitrant exuberant digital calcinosis cutis in a patient of CREST syndrome - A case report · 2022
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata