Definition
US FDA substance register · UNII H5WVD9LZUD · registered name SODIUM ACID PYROPHOSPHATE · single chemical substance
Disodium dihydrogenpyrophosphate
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ピロリン酸２Ｎａ: 本品は、ピロリン酸の二ナトリウム塩であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 7758-16-9
- EC No.EU chemical inventory number
- 231-835-0
- DTXSIDUS EPA chemical ID
- DTXSID7044261
- DTXCIDUS EPA compound ID
- DTXCID408842
- IUPAC
- Disodium dihydrogen diphosphate
- Molecular formula
- H2Na2O7P2
- Molecular weight
- 221.936 g/mol
Measured properties
- Appearance
- solid
- Colour
- white
- Odour
- odourless
- pH
- 4.3
- Melting/freezing point
- 200 ℃
- Water solubility
- 120000 ㎎/ℓ
- Vapour density
- 7.7
- Relative density
- 1.862
- Decomposition temperature
- 220 ℃
- Molecular weight
- 221.94
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 43 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- pH regulating agent9
- Corrosion inhibitor6
- Dispersing agent4
- Chelating agent4
- Processing aids not otherwise specified3
- Flavouring and nutrient3
- Tanning agents not otherwise specified2
- Oxidizing agent2
9 other uses
- Softener and conditioner2
- Other1
- Chemical reaction regulator1
- Emulsifier1
- Food preservative (EPA)1
- Filler1
- Leavening agent (EPA)1
- Dye1
- Surfactant (surface active agent)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) equivalent or similar to - Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening - Ambiguous
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Severe Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- Tlooto literature search
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese