L-1,4-dithiothreitol is a 1,4-dithiothreitol.
Definition
L-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a D-1,4-dithiothreitol.
Source: PubChem
US FDA substance register · UNII T8ID5YZU6Y · registered name DITHIOTHREITOL · single chemical substance
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 3483-12-3
- EC No.EU chemical inventory number
- 222-468-7
- DTXSIDUS EPA chemical ID
- DTXSID5041017
- DTXCIDUS EPA compound ID
- DTXCID00820548
- IUPAC
- (2S,3S)-1,4-Bis(sulfanyl)butane-2,3-diol
- Molecular formula
- C4H10O2S2
- Molecular weight
- 154.24 g/mol
Measured properties
- Appearance
- Slightly hygroscopic solid, [Merck Index] White powder, [Sigma-Aldrich MSDS] · Solid
- Odour
- Characteristic
- Boiling point
- BP: 115-116 °C at 1 mm Hg · Can be sublimed at 37 °C and 0.005 mm pressure. BP: 125-130 at 2 mm Hg
- Melting point
- 42-43 °C · 42.50 °C. @ 760.00 mm Hg
- Solubility
- Freely soluble in water · Freely soluble in ethanol, acetone, ethyl acetate, chloroform, ether
- Stability
- Chemical stability: May decompose on exposure to moist air or water. Stable under recommended storage conditions.
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Reducing agent1
- Hair waving or straightening (EPA)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Stoichiometry of the Reaction Catalyzed by Skin Sulfhydryl Oxidase · 1994
- Fine structure of the epidermal basement membrane of the lip: applications of dithiothreitol separation and ultrathin frozen sectioning. · 1995
- Effects of Dithiothreitol and Ascorbate on the Penetration of Diclofenac Across Excised Rat Dorsal Skin · 1988
- Unexpected positive cultures of humeral head detected with Dithiothreitol in primary shoulder arthroplasty. · 2024
- The Contribution of Dithiothreitol Separation to the Morphological Studies of the Epidermal and the Epithelial Basement Membranes · 1999
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI 2
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese