What is this ingredient?

미국 FDA 물질 등록 · UNII BYR0546TOW · 등록명 DMDM HYDANTOIN · 단일 화학물질

All ingredients

Ingredient Dictionary

DMDM HYDANTOIN

Korean limit: 0.6%

How much products actually contain

No product states its amount yet.

Of the products containing it, 8 list it before the 1% line and 17 after it (usually 1% or less).

Products using this ingredient

12 of 25 confirmed · likeliest to carry enough first · See all 25

Definition

US FDA substance register · UNII BYR0546TOW · registered name DMDM HYDANTOIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

DMDM Hydantoin is the organic compound that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Allowed preservative: United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.6%

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.6%

Taiwan

Maximum concentration : 0.6%
0.6%

Japan

Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.30 g

China · South Korea

Maximum concentration : 0.6%

European Union

Maximum concentration in ready for use preparation : 0.6%

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 33 · maximum concentration 0.6%

Source: EU allowed preservatives (Annex V)

Restriction V/33 · SCCS opinion: SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of DMDM Hydantoin

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ＤＭＤＭヒダントイン: 本品は、次の化学式で表される化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

DMDM HYDANTOININCI디엠디엠하이단토인Korean label name (MFDS standard)디엠디엠하이단토인 (1,3-비스(히드록시메칠)-5,5-디메칠이미다졸리딘-2,4-디온)Korean label name (MFDS standard)2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-SynonymＤＭＤＭヒダントインJapanese labelling name

CAS No.chemical registry number: 6440-58-0
EC No.EU chemical inventory number: 229-222-8
DTXSIDUS EPA chemical ID: DTXSID8035217
DTXCIDUS EPA compound ID: DTXCID6015217

IUPAC: 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
Molecular formula: C7H12N2O4
Molecular weight: 188.183 g/mol

Measured properties

Appearance: solid
Colour: colourless
Odour: odourless
Melting/freezing point: 102~104 ℃
Vapour pressure: 0.00000000106 ㎜Hg (at 25 ℃, est.)
Water solubility: 261000 ㎎/ℓ (at 25 ℃, in water, est.)
n-Octanol/water partition coefficient (Kow): -2.37 (est.)
Molecular weight: 188.21

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 285 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative280
No specific technical function1
Processing aids not otherwise specified1
Fragrance1
Intermediate1
Biocide1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 1 eye studies are on record.

Classed as moderate1Classed as low2

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 6.3B (Category 3)
Skin Irritation · Read Across
Sh
Skin Sensitization · Authoritative
SkinIrr2
Skin Irritation · QSAR Predicted
SkinSens1
Skin Sensitization · QSAR Predicted
Moderate or Mild Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to
Moderate or Mild Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to