Ingredient Dictionary

DODECANEDIOIC ACID

Dodecanedioic acid is an alpha,-dicarboxylic acid that is dodecane in which the methyl groups have been oxidised to the corresponding carboxylic acids.

Definition

Dodecanedioic acid is an alpha,-dicarboxylic acid that is dodecane in which the methyl groups have been oxidised to the corresponding carboxylic acids. It has a role as an EC 1.1.1.1 (alcohol dehydrogenase) inhibitor and a human metabolite. It is a dicarboxylic fatty acid and an alpha,omega-dicarboxylic acid. It is a conjugate acid of a dodecanedioate(2-). It derives from a hydride of a dodecane.

Source: PubChem

US FDA substance register · UNII 978YU42Q6I · registered name DODECANEDIOIC ACID · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts and Esters

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

DODECANEDIOIC ACIDINCI도데케인다이오익애씨드Korean label name (MFDS standard)

CAS No.chemical registry number: 693-23-2
EC No.EU chemical inventory number: 211-746-3
DTXSIDUS EPA chemical ID: DTXSID3027297
DTXCIDUS EPA compound ID: DTXCID607297

IUPAC: Dodecanedioic acid
Molecular formula: C12H22O4
Molecular weight: 230.304 g/mol

Measured properties

Appearance: Liquid, Other Solid, Dry Powder, CBI · White solid, [Hawley]
Melting point: 130-132 °C · 127 - 129 °C
Solubility: SOL IN HOT TOLUENE, ALC, HOT ACETIC ACID, SLIGHTLY SOL IN HOT WATER · 0.04 mg/mL
Melting/freezing point: 128 ℃
Initial boiling point and range: 250 ℃
Flash point: 220 ℃
Flammability (solid, gas): flammable
Vapour pressure: 0 hPa(at 20℃)
Water solubility: 40 ㎎/ℓ(at 20℃)
Vapour density: 7.95
Relative density: 1.172 (at 20℃)
n-Octanol/water partition coefficient (Kow): 3.17 (est.)
Auto-ignition temperature: 390 ℃
Molecular weight: 230.31

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 16 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Lubricating agent3
Monomers3
Plasticizer3
Corrosion inhibitor2
Chemical reaction regulator2
Processing aids not otherwise specified1
Softener and conditioner1
Flow promoter1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to