Drometrizole is a member of triazoles.
- Korean limit
- 1%
How much products actually contain
No product states its amount yet.
Of the products containing it, 6 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
6 of 6 confirmed · likeliest to carry enough first
Definition
Drometrizole is a member of triazoles.
Source: PubChem
US FDA substance register · UNII 5X93W9OFZL · registered name DROMETRIZOLE · single chemical substance
Cosmetic roles
Safety & regulatory references
Japan
- Maximum amount per 100 g(Maximum amount of ingredient per 100 g) : 7.0 g(7.0 g)
South Korea
- Maximum concentration : 1%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Drometrizole
Reviewed by CIR: Amended Final Report on the Safety Assessment of Drometrizole as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ドロメトリゾール: 本品は、次の化学式で表されるベンゾトリアゾールの誘導体である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 2440-22-4
- EC No.EU chemical inventory number
- 219-470-5
- DTXSIDUS EPA chemical ID
- DTXSID1027479
- DTXCIDUS EPA compound ID
- DTXCID207479
- IUPAC
- 2-(2H-1,2,3-Benzotriazol-2-yl)-4-methylphenol
- Molecular formula
- C13H11N3O
- Molecular weight
- 225.251 g/mol
Measured properties
- Appearance
- Dry Powder, Other Solid, Large Crystals
- Odour
- odourless
- Melting/freezing point
- 128~133 ℃
- Initial boiling point and range
- 225 ℃( at 10 mmHg)
- Flash point
- 205 ℃()
- Vapour pressure
- 0.0000000795 ㎜Hg (at 25℃ (est.))
- Water solubility
- 25.6 ㎎/ℓ (at 25℃ (est.))
- Relative density
- 1.51 ()
- n-Octanol/water partition coefficient (Kow)
- 4.31
- Molecular weight
- 225.25
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 63 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- UV stabilizer35
- Dye21
- Processing aids not otherwise specified3
- Stabilizing agent1
- Photosensitive agent1
- Fragrance1
- Antioxidant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: US FDA - Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) according to - Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - 1981 followed, reliability scoring based on 1992 guideline - SkinIrr2
Skin Irritation · QSAR Predicted - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber · 2019
- British Society for Cutaneous Allergy · 2018
- Thermographic proof of “Flare up syndrome” in patient with allergy to acrylic materials · 2018
- Amended final report of the safety assessment of Drometrizole as used in cosmetics. · 2008
- Sunscreens – what's important to know · 2008
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata